Seroatlas · Human Serome Atlas

PCMTD1

Protein-L-isoaspartate O-methyltransferase domain-containing protein 1

Also known as: FLJ10883, PCMD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MG8
Gene: PCMTD1
Ensembl: ENSG00000168300
Chromosome: 8
Canonical length: 357 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination. Part of Cul5-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q96MG8|PCMTD1
     1  MGGAVSAGED NDDLIDNLKE AQYIRTERVE QAFRAIDRGD YYLEGYRDNA YKDLAWKHGN
    61  IHLSAPCIYS EVMEALKLQP GLSFLNLGSG TGYLSTMVGL ILGPFGINHG IELHSDVVEY
   121  AKEKLESFIK NSDSFDKFEF CEPAFVVGNC LQIASDSHQY DRIYCGAGVQ KDHENYMKIL
   181  LKVGGILVMP IEDQLTQIMR TGQNTWESKN ILAVSFAPLV QPSKNDNGKP DSVGLPPCAV
   241  RNLQDLARIY IRRTLRNFIN DEMQAKGIPQ RAPPKRKRKR VKQRINTYVF VGNQLIPQPL
   301  DSEEDEKMEE DNKEEEEKDH NEAMKPEEPP QNLLREKIMK LPLPESLKAY LTYFRDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCMTD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 78 nTPM
parathyroid gland: 73 nTPM
pancreas: 66 nTPM
tongue: 63 nTPM
salivary gland: 54 nTPM
thyroid gland: 50 nTPM

Single-cell type

neutrophils: 603 nCPM
myonuclei: 567 nCPM
neutrophil progenitors: 404 nCPM
platelets: 376 nCPM
pancreatic acinar cells: 332 nCPM
podocytes: 331 nCPM

Immune cell

neutrophil: 30 nTPM
eosinophil: 23 nTPM
NK-cell: 22 nTPM
basophil: 19 nTPM
plasmacytoid DC: 15 nTPM
naive CD4 T-cell: 14 nTPM

Brain region

cerebellum: 45 nTPM
choroid plexus: 41 nTPM
white matter: 36 nTPM
hypothalamus: 34 nTPM
basal ganglia: 34 nTPM
pons: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.27
gnomAD missense Z: 2.61
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein ubiquitination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCMTD1 as an antibody target. Whether an autoantibody or antibody against PCMTD1 could matter depends on whether native PCMTD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCMTD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCMTD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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