Seroatlas · Human Serome Atlas

PCLAF

PCNA-associated factor

Also known as: KIAA0101, NS5ATP9, OEATC-1, p15(PAF), PAF15, PAF15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15004
Gene: PCLAF
Ensembl: ENSG00000166803
Chromosome: 15
Canonical length: 111 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Enables chromatin binding activity and molecular adaptor activity. Involved in several processes, including DNA metabolic process; centrosome cycle; and response to UV. Located in centrosome; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

111 residues, UniProt reviewed canonical sequence.

>Q15004|PCLAF
     1  MVRTKADSVP GTYRKVVAAR APRKVLGSST SATNSTSVSS RKAENKYAGG NPVCVRPTPK
    61  WQKGIGEFFR LSPKDSEKEN QIPEEAGSSG LGKAKRKACP LQPDHTNDEK E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCLAF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 121 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 121 nTPM
thymus: 69 nTPM
lymph node: 46 nTPM
tonsil: 44 nTPM
appendix: 22 nTPM
rectum: 21 nTPM

Single-cell type

late spermatids: 165 nCPM
early spermatids: 30 nCPM
erythrocyte progenitors: 27 nCPM
monocyte progenitors: 17 nCPM
megakaryocyte progenitors: 14 nCPM
gastric progenitor cells: 14 nCPM

Immune cell

T-reg: 24 nTPM
NK-cell: 5.7 nTPM
memory CD4 T-cell: 4.4 nTPM
memory CD8 T-cell: 4.2 nTPM
myeloid DC: 2.9 nTPM
neutrophil: 2.5 nTPM

Brain region

white matter: 5.8 nTPM
cerebellum: 5 nTPM
medulla oblongata: 4.3 nTPM
cerebral cortex: 4.2 nTPM
thalamus: 4.2 nTPM
basal ganglia: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.16
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

PCNA-associated factor, histone-like domain
PCNA-associated factor
PCNA-associated factor histone like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCLAF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCLAF as an antibody target. Whether an autoantibody or antibody against PCLAF could matter depends on whether native PCLAF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCLAF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCLAF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...