Seroatlas · Human Serome Atlas

PCED1B

PC-esterase domain-containing protein 1B

Also known as: FAM113B, MGC16044, PED1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HM7
Gene: PCED1B
Ensembl: ENSG00000179715
Chromosome: 12
Canonical length: 432 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a protein that belongs to the GDSL/SGNH-like acyl-esterase family. Members of this family are hydrolases thought to function in modification of biopolymers on the cell surface. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q96HM7|PCED1B
     1  MILLRASEVR QLLHNKFVVI LGDSVHRAVY KDLVLLLQKD RLLTPGQLRA RGELNFEQDE
    61  LVDGGQRGHM HNGLNYREVR EFRSDHHLVR FYFLTRVYSD YLQTILKELQ SGEHAPDLVI
   121  MNSCLWDISR YGPNSWRSYL ENLENLFQCL GQVLPESCLL VWNTAMPVGE EVTGGFLPPK
   181  LRRQKATFLK NEVVKANFHS ATEARKHNFD VLDLHFHFRH ARENLHWDGV HWNGRVHRCL
   241  SQLLLAHVAD AWGVELPHRH PVGEWIKKKK PGPRVEGPPQ ANRNHPALPL SPPLPSPTYR
   301  PLLGFPPQRL PLLPLLSPQP PPPILHHQGM PRFPQGPPDA CFSSDHTFQS DQFYCHSDVP
   361  SSAHAGFFVE DNFMVGPQLP MPFFPTPRYQ RPAPVVHRGF GRYRPRGPYT PWGQRPRPSK
   421  RRAPANPEPR PQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCED1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 39 nTPM
lymph node: 34 nTPM
spleen: 28 nTPM
ovary: 25 nTPM
tonsil: 23 nTPM
appendix: 17 nTPM

Single-cell type

podocytes: 631 nCPM
adipocytes: 351 nCPM
t-cells: 274 nCPM
adrenal cortex cells: 248 nCPM
renal collecting duct intercalated cells: 239 nCPM
prostatic hillock cells: 222 nCPM

Immune cell

naive CD4 T-cell: 89 nTPM
naive CD8 T-cell: 84 nTPM
T-reg: 59 nTPM
memory CD8 T-cell: 54 nTPM
memory CD4 T-cell: 51 nTPM
memory B-cell: 50 nTPM

Brain region

midbrain: 11 nTPM
white matter: 9.8 nTPM
medulla oblongata: 9.6 nTPM
thalamus: 9.2 nTPM
hypothalamus: 8.5 nTPM
pons: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.93
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

SGNH hydrolase superfamily

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCED1B as an antibody target. Whether an autoantibody or antibody against PCED1B could matter depends on whether native PCED1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCED1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCED1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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