Seroatlas · Human Serome Atlas

PCED1A

PC-esterase domain-containing protein 1A

Also known as: bA12M19.1, C20orf81, FAM113A, FLJ22376, PED1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H1Q7
Gene
PCED1A
Ensembl
ENSG00000132635
Chromosome
20
Canonical length
454 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>Q9H1Q7|PCED1A
     1  MVFCLSSEEP RRPLRSDMVH FQASEVQQLL HNKFVVILGD SIQRAVYKDL VLLLQKDSLL
    61  TAAQLKAKGE LSFEQDQLVA GGQLGELHNG TQYREVRQFC SGSGHHLVRF YFLTRVYSEY
   121  LEDVLEELTY GPAPDLVIIN SCLWDLSRYG RCSMESYREN LERVFVRMDQ VLPDSCLLVW
   181  NMAMPLGERI TGGFLLPELQ PLAGSLRRDV VEGNFYSATL AGDHCFDVLD LHFHFRHAVQ
   241  HRHRDGVHWD QHAHRHLSHL LLTHVADAWG VELPKRGYPP DPWIEDWAEM NHPFQGSHRQ
   301  TPDFGEHLAL LPPPPSSLPP PMPFPYPLPQ PSPPPLFPPL PQDTPFFPGQ PFPPHEFFNY
   361  NPVEDFSMPP HLGCGPGVNF VPGPLPPPIP GPNPHGQHWG PVVHRGMPRY VPNSPYHVRR
   421  MGGPCRQRLR HSERLIHTYK LDRRPPAHSG TWPG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCED1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
88 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 88 nTPM
  • spleen: 82 nTPM
  • kidney: 71 nTPM
  • prostate: 67 nTPM
  • ovary: 65 nTPM
  • pituitary gland: 65 nTPM

Single-cell type

  • endometrial stromal cells: 33 nCPM
  • gastric chief cells: 26 nCPM
  • proximal tubule cells: 26 nCPM
  • choroid plexus epithelial cells: 26 nCPM
  • mesothelial cells: 26 nCPM
  • megakaryocyte-erythroid progenitors: 24 nCPM

Immune cell

  • NK-cell: 16 nTPM
  • naive CD4 T-cell: 12 nTPM
  • gdT-cell: 11 nTPM
  • MAIT T-cell: 11 nTPM
  • naive CD8 T-cell: 11 nTPM
  • memory B-cell: 9.9 nTPM

Brain region

  • choroid plexus: 64 nTPM
  • white matter: 64 nTPM
  • cerebral cortex: 57 nTPM
  • medulla oblongata: 55 nTPM
  • thalamus: 53 nTPM
  • basal ganglia: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.09
gnomAD missense Z
0.69
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • PC-esterase domain-containing protein 1A domain

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCED1A as an antibody target. Whether an autoantibody or antibody against PCED1A could matter depends on whether native PCED1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCED1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCED1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PCED1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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