Seroatlas · Human Serome Atlas

PBOV1

Prostate and breast cancer overexpressed gene 1 protein

Also known as: PBOV1_HUMAN, UC28, UROC28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZY1
Gene
PBOV1
Ensembl
ENSG00000254440
Chromosome
6
Canonical length
135 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This intronless gene encodes a protein of unknown function. Its expression is up-regulated in some types of cancer, including prostate, breast, and bladder cancer. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

135 residues, UniProt reviewed canonical sequence.

>Q9GZY1|PBOV1
     1  MRAFLRNQKY EDMHNIIHIL QIRKLRHRLS NFPRLPGILA PETVLLPFCY KVFRKKEKVK
    61  RSQKATEFID YSIEQSHHAI LTPLQTHLTM KGSSMKCSSL SSEAILFTLT LQLTQTLGLE
   121  CCLLYLSKTI HPQII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PBOV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 0.2 nTPM
  • cerebellum: 0.1 nTPM
  • kidney: 0.1 nTPM
  • pancreas: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • epicardial cells: 36 nCPM
  • mesothelial cells: 0.7 nCPM
  • salivary acinar cells: 0.7 nCPM
  • cardiomyocytes: 0.6 nCPM
  • thyrotrophs: 0.6 nCPM
  • oligodendrocytes: 0.4 nCPM

Immune cell

  • basophil: 0.7 nTPM
  • neutrophil: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • white matter: 11 nTPM
  • cerebellum: 9.9 nTPM
  • hippocampal formation: 6.8 nTPM
  • basal ganglia: 6.5 nTPM
  • cerebral cortex: 6.5 nTPM
  • medulla oblongata: 6.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
-0.4
DepMap mean gene effect
0.24
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PBOV1 as an antibody target. Whether an autoantibody or antibody against PBOV1 could matter depends on whether native PBOV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PBOV1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PBOV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PBOV1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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