Seroatlas · Human Serome Atlas

PBDC1

Protein PBDC1

Also known as: CXorf26, MGC874, PBDC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVG4
Gene: PBDC1
Ensembl: ENSG00000102390
Chromosome: X
Canonical length: 233 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

No narrative summary is available for PBDC1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>Q9BVG4|PBDC1
     1  MAATSGTDEP VSGELVSVAH ALSLPAESYG NDPDIEMAWA MRAMQHAEVY YKLISSVDPQ
    61  FLKLTKVDDQ IYSEFRKNFE TLRIDVLDPE ELKSESAKEK WRPFCLKFNG IVEDFNYGTL
   121  LRLDCSQGYT EENTIFAPRI QFFAIEIARN REGYNKAVYI SVQDKEGEKG VNNGGEKRAD
   181  SGEEENTKNG GEKGADSGEE KEEGINREDK TDKGGEKGKE ADKEINKSGE KAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PBDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 44 nTPM
duodenum: 38 nTPM
esophagus: 33 nTPM
small intestine: 31 nTPM
urinary bladder: 31 nTPM
adrenal gland: 31 nTPM

Single-cell type

esophageal suprabasal cells: 145 nCPM
ocular epithelial cells: 130 nCPM
esophageal basal cells: 120 nCPM
epididymal basal cells: 118 nCPM
enterocytes: 95 nCPM
esophageal apical cells: 90 nCPM

Immune cell

non-classical monocyte: 72 nTPM
memory B-cell: 71 nTPM
NK-cell: 70 nTPM
gdT-cell: 69 nTPM
memory CD8 T-cell: 68 nTPM
intermediate monocyte: 63 nTPM

Brain region

midbrain: 17 nTPM
hypothalamus: 16 nTPM
cerebral cortex: 16 nTPM
medulla oblongata: 16 nTPM
pons: 15 nTPM
thalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.57
gnomAD missense Z: 0.68
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein PBDC1, metazoa/fungi
Polysaccharide biosynthesis domain
PBDC1-like domain superfamily
PBDC1 protein

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PBDC1 as an antibody target. Whether an autoantibody or antibody against PBDC1 could matter depends on whether native PBDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PBDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PBDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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