Seroatlas · Human Serome Atlas

PATL2

Protein PAT1 homolog 2

Also known as: Pat1a, PATL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9JE40
Gene: PATL2
Ensembl: ENSG00000229474
Chromosome: 15
Canonical length: 543 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable RNA binding activity. Predicted to be involved in P-body assembly; deadenylation-dependent decapping of nuclear-transcribed mRNA; and negative regulation of translation. Predicted to act upstream of or within negative regulation of cytoplasmic mRNA processing body assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>C9JE40|PATL2
     1  MNCLEGPGKT CGPLASEEEL VSACQLEKEE ENEGEEEEEE EDEEDLDPDL DPDLEEEEND
    61  LGDPAVLGAV HNTQRALLSS PGVKAPGMLG MSLASLHFLW QTLDYLSPIP FWPTFPSTSS
   121  PAQHFGPRLP SPDPTLFCSL LTSWPPRFSH LTQLHPRHQR ILQQQQHSQT PSPPAKKPWS
   181  QQPDPYANLM TRKEKDWVIK VQMVQLQSAK PRLDDYYYQE YYQKLEKKQA DEELLGRRNR
   241  VESLKLVTPY IPKAEAYESV VRIEGSLGQV AVSTCFSPRR AIDAVPHGTQ EQDIEAASSQ
   301  RLRVLYRIEK MFLQLLEIEE GWKYRPPPPC FSEQQSNQVE KLFQTLKTQE QNNLEEAADG
   361  FLQVLSVRKG KALVARLLPF LPQDQAVTIL LAITHHLPLL VRRDVADQAL QMLFKPLGKC
   421  ISHLTLHELL QGLQGLTLLP PGSSERPVTV VLQNQFGISL LYALLSHGEQ LVSLHSSLEE
   481  PNSDHTAWTD MVVLIAWEIA QMPTASLAEP LAFPSNLLPL FCHHVDKQLV QQLEARMEFA
   541  WIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PATL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

lymph node: 16 nTPM
spleen: 13 nTPM
tonsil: 10 nTPM
appendix: 7.3 nTPM
bone marrow: 7.3 nTPM
lung: 3.7 nTPM

Single-cell type

oocytes: 97 nCPM
nk-cells: 26 nCPM
b-cells: 23 nCPM
t-cells: 22 nCPM
neutrophils: 22 nCPM
microglia: 20 nCPM

Immune cell

gdT-cell: 22 nTPM
memory CD8 T-cell: 18 nTPM
naive CD8 T-cell: 14 nTPM
memory CD4 T-cell: 6.5 nTPM
neutrophil: 5.4 nTPM
basophil: 4.5 nTPM

Brain region

medulla oblongata: 3.6 nTPM
choroid plexus: 2.8 nTPM
white matter: 2.5 nTPM
thalamus: 2.3 nTPM
midbrain: 2 nTPM
pons: 2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PATL2.

Disease | AllUniProt

Conditions PATL2 is implicated in, by any mechanism.

Oocyte/zygote/embryo maturation arrest 4 (OZEMA4) MIM:617743

Disease | GeneticClinVar

20 pathogenic / likely-pathogenic of 114 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Oocyte maturation defect 4
Oocyte maturation defect 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 1.48
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PATL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LSM1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PATL2 as an antibody target. Whether an autoantibody or antibody against PATL2 could matter depends on whether native PATL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PATL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PATL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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