Seroatlas · Human Serome Atlas

PATE4

Prostate and testis expressed protein 4

Also known as: FLJ41047, PATE-B, PATE4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C8F1
Gene
PATE4
Ensembl
ENSG00000237353
Chromosome
11
Canonical length
98 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

Enables acetylcholine receptor regulator activity. Involved in regulation of neurotransmitter receptor activity. Located in acrosomal vesicle and extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

98 residues, UniProt reviewed canonical sequence.

>P0C8F1|PATE4
     1  MRKMNTLLLV SLSFLYLKEV MGLKCNTCIY TEGWKCMAGR GTCIAKENEL CSTTAYFRGD
    61  KHMYSTHMCK YKCREEESSK RGLLRVTLCC DRNFCNVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PATE4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
101 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 101 nTPM
  • epididymis: 14 nTPM
  • prostate: 2.4 nTPM
  • retina: 0.6 nTPM
  • skin: 0.4 nTPM
  • testis: 0.4 nTPM

Single-cell type

  • epididymal principal cells: 286 nCPM
  • late spermatids: 27 nCPM
  • early spermatids: 24 nCPM
  • late primary spermatocytes: 13 nCPM
  • epididymal clear cells: 6.1 nCPM
  • epididymal basal cells: 2.9 nCPM

Immune cell

  • plasmacytoid DC: 0.2 nTPM
  • basophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • cerebellum: 15 nTPM
  • cerebral cortex: 13 nTPM
  • white matter: 13 nTPM
  • basal ganglia: 12 nTPM
  • hypothalamus: 12 nTPM
  • amygdala: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.85
gnomAD pLI
0
gnomAD missense Z
0.18
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PATE4 as an antibody target. Whether an autoantibody or antibody against PATE4 could matter depends on whether native PATE4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PATE4 is annotated as secreted, so native PATE4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PATE4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PATE4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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