Seroatlas · Human Serome Atlas

PATE2

Prostate and testis expressed protein 2

Also known as: C11orf38, LVLF3112, PATE-M, PATE2_HUMAN, UNQ3112

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UY27
Gene
PATE2
Ensembl
ENSG00000196844
Chromosome
11
Canonical length
113 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q6UY27|PATE2
     1  MLVLFLLGTV FLLCPYWGEL HDPIKATEIM CYECKKYHLG LCYGVMTSCS LKHKQSCAVE
    61  NFYILTRKGQ SMYHYSKLSC MTSCEDINFL GFTKRVELIC CDHSNYCNLP EGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PATE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
425 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 425 nTPM
  • seminal vesicle: 33 nTPM
  • testis: 1 nTPM
  • retina: 0.4 nTPM
  • cerebral cortex: 0.2 nTPM
  • pituitary gland: 0.2 nTPM

Single-cell type

  • epididymal principal cells: 600 nCPM
  • late spermatids: 27 nCPM
  • epididymal clear cells: 8.2 nCPM
  • retinal ganglion cells: 7.7 nCPM
  • epididymal basal cells: 6.2 nCPM
  • early spermatids: 5.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 7.9 nTPM
  • white matter: 7.3 nTPM
  • basal ganglia: 7.1 nTPM
  • hypothalamus: 6.6 nTPM
  • amygdala: 6.5 nTPM
  • pons: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0
gnomAD missense Z
-0.3
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PATE2 as an antibody target. Whether an autoantibody or antibody against PATE2 could matter depends on whether native PATE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PATE2 is annotated as secreted, so native PATE2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PATE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PATE2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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