Seroatlas · Human Serome Atlas

PATE1

Prostate and testis expressed protein 1

Also known as: PATE, PATE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WXA2
Gene
PATE1
Ensembl
ENSG00000171053
Chromosome
11
Canonical length
126 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in male reproductive system

OverviewNCBI Gene

Predicted to enable acetylcholine receptor regulator activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>Q8WXA2|PATE1
     1  MDKSLLLELP ILLCCFRALS GSLSMRNDAV NEIVAVKNNF PVIEIVQCRM CHLQFPGEKC
    61  SRGRGICTAT TEEACMVGRM FKRDGNPWLT FMGCLKNCAD VKGIRWSVYL VNFRCCRSHD
   121  LCNEDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PATE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
1,764 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 1,764 nTPM
  • seminal vesicle: 197 nTPM
  • prostate: 2.4 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • epididymal principal cells: 1,635 nCPM
  • epididymal basal cells: 13 nCPM
  • epididymal clear cells: 10 nCPM
  • retinal horizontal cells: 4 nCPM
  • epididymal efferent duct ciliated cells: 3.4 nCPM
  • mast cells: 2.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.6 nTPM
  • basal ganglia: 1.2 nTPM
  • hypothalamus: 1 nTPM
  • white matter: 1 nTPM
  • amygdala: 0.8 nTPM
  • pons: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.95
gnomAD pLI
0
gnomAD missense Z
-0.48
DepMap mean gene effect
0.34
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PATE1 as an antibody target. Whether an autoantibody or antibody against PATE1 could matter depends on whether native PATE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PATE1 is annotated as secreted, so native PATE1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PATE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PATE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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