Seroatlas · Human Serome Atlas

PARP8

Protein mono-ADP-ribosyltransferase PARP8

Also known as: ARTD16, FLJ21308, PARP8_HUMAN, pART16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3A8
Gene: PARP8
Ensembl: ENSG00000151883
Chromosome: 5
Canonical length: 854 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Midbody ring,Cytosol

OverviewNCBI Gene

Enables NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

854 residues, UniProt reviewed canonical sequence.

>Q8N3A8|PARP8
     1  MGMCSRQERI QKDIDVVIQK SRAEKDCLFA DFRYSDSTFT FTYVGGPRSV SYSVHVSEDY
    61  PDNTYVSSSE NDEDVLVTTE PIPVIFHRIA TELRKTNDIN CCLSIKSKLQ KENGEESRQN
   121  STVEEDSEGD NDSEEFYYGG QVNYDGELHK HPQLEADLSA VREIYGPHAV SLREYGAIDD
   181  VDIDLHIDVS FLDEEIAVAW EVIRTEPIIV RLHCSLTQYL NGPVPTVDVF QISTKERFGL
   241  GHQLKKIMQT FVTQQWKQSK EKSNCLHNKK LSEKKVKSPL HLFSTLRRSP SYPPPGCGKS
   301  KSKLKSEQDG ISKTHKLLRR TCSSTVKTDD VCVTKSHRTF GRSLSSDPRA EQAMTAIKSH
   361  KLLNRPCPAA VKSEECLTLK SHRLLTRSCS GDPRCEHNTN LKPHKLLSRS YSSNLRMEEL
   421  YGLKNHKLLS KSYSSAPKSS KTELFKEPNA EGRRLSLTSG LIGILTPSSS SSSQLAPNGA
   481  KCIPVRDRGF LVQTIEFAEQ RIPVLNEYCV VCDEPHVFQN GPMLRPTVCE RELCVFAFQT
   541  LGVMNEAADE IATGAQVVDL LVSMCRSALE SPRKVVIFEP YPSVVDPNDP QMLAFNPRKK
   601  NYDRVMKALD SITSIREMTQ APYLEIKKQM DKQDPLAHPL LQWVISSNRS HIVKLPVNRQ
   661  LKFMHTPHQF LLLSSPPAKE SNFRAAKKLF GSTFAFHGSH IENWHSILRN GLVVASNTRL
   721  QLHGAMYGSG IYLSPMSSIS FGYSGMNKKQ KVSAKDEPAS SSKSSNTSQS QKKGQQSQFL
   781  QSRNLKCIAL CEVITSSDLH KHGEIWVVPN TDHVCTRFFF VYEDGQVGDA NINTQEGGIH
   841  KEILRVIGNQ TATG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARP8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 82 nTPM
spleen: 43 nTPM
lymph node: 42 nTPM
thyroid gland: 42 nTPM
appendix: 28 nTPM
gallbladder: 26 nTPM

Single-cell type

neutrophils: 1,887 nCPM
t-cells: 1,714 nCPM
nk-cells: 1,462 nCPM
neutrophil progenitors: 717 nCPM
innate lymphoid cells: 613 nCPM
monocyte progenitors: 455 nCPM

Immune cell

MAIT T-cell: 73 nTPM
memory CD8 T-cell: 50 nTPM
gdT-cell: 43 nTPM
NK-cell: 41 nTPM
naive CD8 T-cell: 34 nTPM
memory CD4 T-cell: 34 nTPM

Brain region

hippocampal formation: 78 nTPM
hypothalamus: 73 nTPM
cerebral cortex: 65 nTPM
basal ganglia: 64 nTPM
midbrain: 58 nTPM
medulla oblongata: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.06
gnomAD missense Z: 2
DepMap mean gene effect: 0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARP8 as an antibody target. Whether an autoantibody or antibody against PARP8 could matter depends on whether native PARP8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARP8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PARP8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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