Seroatlas · Human Serome Atlas

PARP6

Protein mono-ADP-ribosyltransferase PARP6

Also known as: ARTD17, PARP6_HUMAN, pART17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q2NL67
Gene
PARP6
Ensembl
ENSG00000137817
Chromosome
15
Canonical length
630 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

Enables NAD+-protein-aspartate ADP-ribosyltransferase activity and NAD+-protein-cysteine ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

630 residues, UniProt reviewed canonical sequence.

>Q2NL67|PARP6
     1  MDIKGQFWND DDSEGDNESE EFLYGVQGSC AADLYRHPQL DADIEAVKEI YSENSVSIRE
    61  YGTIDDVDID LHINISFLDE EVSTAWKVLR TEPIVLRLRF SLSQYLDGPE PSIEVFQPSN
   121  KEGFGLGLQL KKILGMFTSQ QWKHLSNDFL KTQQEKRHSW FKASGTIKKF RAGLSIFSPI
   181  PKSPSFPIIQ DSMLKGKLGV PELRVGRLMN RSISCTMKNP KVEVFGYPPS PQAGLLCPQH
   241  VGLPPPARTS PLVSGHCKNI PTLEYGFLVQ IMKYAEQRIP TLNEYCVVCD EQHVFQNGSM
   301  LKPAVCTREL CVFSFYTLGV MSGAAEEVAT GAEVVDLLVA MCRAALESPR KSIIFEPYPS
   361  VVDPTDPKTL AFNPKKKNYE RLQKALDSVM SIREMTQGSY LEIKKQMDKL DPLAHPLLQW
   421  IISSNRSHIV KLPLSRLKFM HTSHQFLLLS SPPAKEARFR TAKKLYGSTF AFHGSHIENW
   481  HSILRNGLVN ASYTKLQLHG AAYGKGIYLS PISSISFGYS GMGKGQHRMP SKDELVQRYN
   541  RMNTIPQTRS IQSRFLQSRN LNCIALCEVI TSKDLQKHGN IWVCPVSDHV CTRFFFVYED
   601  GQVGDANINT QDPKIQKEIM RVIGTQVYTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
68 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 68 nTPM
  • cerebral cortex: 50 nTPM
  • retina: 49 nTPM
  • pituitary gland: 47 nTPM
  • basal ganglia: 46 nTPM
  • amygdala: 41 nTPM

Single-cell type

  • late spermatids: 310 nCPM
  • ependymal cells: 83 nCPM
  • astrocytes: 80 nCPM
  • bergmann glia: 73 nCPM
  • sertoli cells: 69 nCPM
  • oligodendrocytes: 65 nCPM

Immune cell

  • eosinophil: 8.3 nTPM
  • classical monocyte: 3.6 nTPM
  • neutrophil: 3.6 nTPM
  • non-classical monocyte: 3.5 nTPM
  • intermediate monocyte: 3.1 nTPM
  • NK-cell: 3 nTPM

Brain region

  • cerebral cortex: 77 nTPM
  • hippocampal formation: 72 nTPM
  • white matter: 71 nTPM
  • basal ganglia: 69 nTPM
  • amygdala: 68 nTPM
  • cerebellum: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
3.18
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARP6 as an antibody target. Whether an autoantibody or antibody against PARP6 could matter depends on whether native PARP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PARP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PARP6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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