Seroatlas · Human Serome Atlas

PARP16

Protein mono-ADP-ribosyltransferase PARP16

Also known as: ARTD15, C15orf30, FLJ20509, FLJ25281, PAR16_HUMAN, pART15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N5Y8
Gene
PARP16
Ensembl
ENSG00000138617
Chromosome
15
Canonical length
322 aa
Protein class
Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Involved in IRE1-mediated unfolded protein response; negative regulation of cytoplasmic translation; and protein auto-ADP-ribosylation. Located in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q8N5Y8|PARP16
     1  MQPSGWAAAR EAAGRDMLAA DLRCSLFASA LQSYKRDSVL RPFPASYARG DCKDFEALLA
    61  DASKLPNLKE LLQSSGDNHK RAWDLVSWIL SSKVLTIHSA GKAEFEKIQK LTGAPHTPVP
   121  APDFLFEIEY FDPANAKFYE TKGERDLIYA FHGSRLENFH SIIHNGLHCH LNKTSLFGEG
   181  TYLTSDLSLA LIYSPHGHGW QHSLLGPILS CVAVCEVIDH PDVKCQTKKK DSKEIDRRRA
   241  RIKHSEGGDI PPKYFVVTNN QLLRVKYLLV YSQKPPKRAS SQLSWFSSHW FTVMISLYLL
   301  LLLIVSVINS SAFQHFWNRA KR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARP16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • liver: 13 nTPM
  • ovary: 11 nTPM
  • cervix: 11 nTPM
  • urinary bladder: 9.7 nTPM
  • colon: 9.6 nTPM
  • thymus: 9.4 nTPM

Single-cell type

  • rod photoreceptor cells: 132 nCPM
  • oocytes: 101 nCPM
  • differentiating spermatogonia: 89 nCPM
  • undifferentiated spermatogonia: 73 nCPM
  • retinal bipolar cells: 56 nCPM
  • adrenal cortex cells: 44 nCPM

Immune cell

  • basophil: 20 nTPM
  • neutrophil: 15 nTPM
  • naive CD4 T-cell: 15 nTPM
  • MAIT T-cell: 14 nTPM
  • memory CD8 T-cell: 13 nTPM
  • gdT-cell: 13 nTPM

Brain region

  • cerebellum: 9.5 nTPM
  • cerebral cortex: 5.8 nTPM
  • white matter: 5.6 nTPM
  • basal ganglia: 5.4 nTPM
  • hypothalamus: 5.3 nTPM
  • amygdala: 5.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.48
gnomAD pLI
0
gnomAD missense Z
0.37
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PARP16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARP16 as an antibody target. Whether an autoantibody or antibody against PARP16 could matter depends on whether native PARP16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARP16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PARP16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PARP16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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