Seroatlas · Human Serome Atlas

PARP15

Protein mono-ADP-ribosyltransferase PARP15

Also known as: ARTD7, BAL3, FLJ40597, PAR15_HUMAN, pART7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q460N3
Gene
PARP15
Ensembl
ENSG00000173200
Chromosome
3
Canonical length
678 aa
Protein class
Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables NAD+ binding activity; pentosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and protein poly-ADP-ribosylation. Predicted to be active in cytoplasm and nucleus. Biomarker of atherosclerosis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

678 residues, UniProt reviewed canonical sequence.

>Q460N3|PARP15
     1  MAAPGPLPAA ALSPGAPTPR ELMHGVAGVT SRAGRDREAG SVLPAGNRGA RKASRRSSSR
    61  SMSRDNKFSK KDCLSIRNVV ASIQTKEGLN LKLISGDVLY IWADVIVNSV PMNLQLGGGP
   121  LSRAFLQKAG PMLQKELDDR RRETEEKVGN IFMTSGCNLD CKAVLHAVAP YWNNGAETSW
   181  QIMANIIKKC LTTVEVLSFS SITFPMIGTG SLQFPKAVFA KLILSEVFEY SSSTRPITSP
   241  LQEVHFLVYT NDDEGCQAFL DEFTNWSRIN PNKARIPMAG DTQGVVGTVS KPCFTAYEMK
   301  IGAITFQVAT GDIATEQVDV IVNSTARTFN RKSGVSRAIL EGAGQAVESE CAVLAAQPHR
   361  DFIITPGGCL KCKIIIHVPG GKDVRKTVTS VLEECEQRKY TSVSLPAIGT GNAGKNPITV
   421  ADNIIDAIVD FSSQHSTPSL KTVKVVIFQP ELLNIFYDSM KKRDLSASLN FQSTFSMTTC
   481  NLPEHWTDMN HQLFCMVQLE PGQSEYNTIK DKFTRTCSSY AIEKIERIQN AFLWQSYQVK
   541  KRQMDIKNDH KNNERLLFHG TDADSVPYVN QHGFNRSCAG KNAVSYGKGT YFAVDASYSA
   601  KDTYSKPDSN GRKHMYVVRV LTGVFTKGRA GLVTPPPKNP HNPTDLFDSV TNNTRSPKLF
   661  VVFFDNQAYP EYLITFTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARP15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 60 nTPM
  • tonsil: 47 nTPM
  • lymph node: 41 nTPM
  • small intestine: 37 nTPM
  • appendix: 24 nTPM
  • bone marrow: 21 nTPM

Single-cell type

  • b-cells: 279 nCPM
  • nk-cells: 114 nCPM
  • t-cells: 67 nCPM
  • hematopoietic stem cells: 39 nCPM
  • megakaryocyte progenitors: 36 nCPM
  • megakaryocyte-erythroid progenitors: 33 nCPM

Immune cell

  • memory B-cell: 9.4 nTPM
  • naive B-cell: 9.2 nTPM
  • gdT-cell: 7.1 nTPM
  • MAIT T-cell: 5.8 nTPM
  • memory CD8 T-cell: 5.4 nTPM
  • naive CD8 T-cell: 4.8 nTPM

Brain region

  • cerebellum: 16 nTPM
  • cerebral cortex: 15 nTPM
  • midbrain: 15 nTPM
  • white matter: 14 nTPM
  • basal ganglia: 14 nTPM
  • medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
gnomAD missense Z
0.63
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARP15 as an antibody target. Whether an autoantibody or antibody against PARP15 could matter depends on whether native PARP15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARP15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PARP15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PARP15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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