Seroatlas · Human Serome Atlas

PARM1

Prostate androgen-regulated mucin-like protein 1

Also known as: Cipar1, DKFZP564O0823, PARM1_HUMAN, WSC4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWI2
Gene: PARM1
Ensembl: ENSG00000169116
Chromosome: 4
Canonical length: 310 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Located in several cellular components, including Golgi apparatus; endosome; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q6UWI2|PARM1
     1  MVYKTLFALC ILTAGWRVQS LPTSAPLSVS LPTNIVPPTT IWTSSPQNTD ADTASPSNGT
    61  HNNSVLPVTA SAPTSLLPKN ISIESREEEI TSPGSNWEGT NTDPSPSGFS STSGGVHLTT
   121  TLEEHSSGTP EAGVAATLSQ SAAEPPTLIS PQAPASSPSS LSTSPPEVFS ASVTTNHSST
   181  VTSTQPTGAP TAPESPTEES SSDHTPTSHA TAEPVPQEKT PPTTVSGKVM CELIDMETTT
   241  TFPRVIMQEV EHALSSGSIA AITVTVIAVV LLVFGVAAYL KIRHSSYGRL LDDHDYGSWG
   301  NYNNPLYDDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PARM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 116 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 116 nTPM
rectum: 107 nTPM
heart muscle: 97 nTPM
colon: 86 nTPM
prostate: 79 nTPM
blood vessel: 70 nTPM

Single-cell type

colonocytes: 342 nCPM
alveolar cells type 2: 323 nCPM
thyrotrophs: 248 nCPM
retinal pigment epithelial cells: 230 nCPM
adrenal medulla cells: 223 nCPM
pituicytes/fscs: 202 nCPM

Immune cell

memory B-cell: 8.1 nTPM
naive B-cell: 5.6 nTPM
myeloid DC: 4 nTPM
total PBMC: 0.5 nTPM
intermediate monocyte: 0.3 nTPM
non-classical monocyte: 0.3 nTPM

Brain region

hypothalamus: 88 nTPM
pons: 77 nTPM
cerebral cortex: 72 nTPM
hippocampal formation: 44 nTPM
basal ganglia: 39 nTPM
thalamus: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Prostate androgen-regulated mucin-like protein 1
PARM

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PARM1 as an antibody target. Whether an autoantibody or antibody against PARM1 could matter depends on whether native PARM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PARM1 is annotated at the cell surface, where native PARM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PARM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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