PAPPA-AS1
Protein PAPPAS
Also known as: PAPAS_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for PAPPA-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
102 residues, UniProt reviewed canonical sequence.
>Q5QFB9|PAPPA-AS1
1 MRYGFVRKKH RGLFLTTVAA LPIWNPISEF VKWYKSHKLS QHCIRICGHL CQKHLDMFLS
61 VIGQRWPIDV FSSVFDHQVS AIGSDIIWWF LKLFLVSFFF FFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PAPPA-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.47
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.88
- gnomAD pLI
- 0.3
- gnomAD missense Z
- 0.37
OntologyGO
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PAPPA-AS1 as an antibody target. Whether an autoantibody or antibody against PAPPA-AS1 could matter depends on whether native PAPPA-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PAPPA-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PAPPA-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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