Seroatlas · Human Serome Atlas

PAOX

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Also known as: PAO, PAOX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6QHF9
Gene
PAOX
Ensembl
ENSG00000148832
Chromosome
10
Canonical length
511 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome

OverviewNCBI Gene

Enables polyamine oxidase activity. Involved in polyamine metabolic process and positive regulation of spermidine biosynthetic process. Predicted to be located in cytosol and peroxisomal matrix. Predicted to be active in cytoplasm. Implicated in lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

511 residues, UniProt reviewed canonical sequence.

>Q6QHF9|PAOX
     1  MESTGSVGEA PGGPRVLVVG GGIAGLGAAQ RLCGHSAFPH LRVLEATARA GGRIRSERCF
    61  GGVVEVGAHW IHGPSRGNPV FQLAAEYGLL GEKELSQENQ LVETGGHVGL PSVSYASSGA
   121  SVSLQLVAEM ATLFYGLIDQ TREFLHAAET PVPSVGEYLK KEIGQHVAGW TEDEETRKLK
   181  LAVLNSFFNL ECCVSGTHSM DLVALAPFGE YTVLPGLDCT FSKGYQGLTN CMMAALPEDT
   241  VVFEKPVKTI HWNGSFQEAA FPGETFPVSV ECEDGDRFPA HHVIVTVPLG FLREHLDTFF
   301  DPPLPAEKAE AIRKIGFGTN NKIFLEFEEP FWEPDCQLIQ LVWEDTSPLE DAAPELQDAW
   361  FRKLIGFVVL PAFASVHVLC GFIAGLESEF METLSDEEVL LCLTQVLRRV TGNPRLPAPK
   421  SVLRSRWHSA PYTRGSYSYV AVGSTGGDLD LLAQPLPADG AGAQLQILFA GEATHRTFYS
   481  TTHGALLSGW READRLLSLW APQVQQPRPR L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAOX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • testis: 27 nTPM
  • liver: 7.6 nTPM
  • esophagus: 5.1 nTPM
  • spleen: 4.4 nTPM
  • spinal cord: 3.9 nTPM
  • small intestine: 3.4 nTPM

Single-cell type

  • tuft cells: 12 nCPM
  • renal collecting duct principal cells: 9.6 nCPM
  • proximal tubule cells: 7.8 nCPM
  • papillary tip epithelial cells: 7.5 nCPM
  • renal collecting duct intercalated cells: 5.7 nCPM
  • loop of henle epithelial cells: 5.1 nCPM

Immune cell

  • naive B-cell: 0.8 nTPM
  • memory B-cell: 0.6 nTPM
  • myeloid DC: 0.3 nTPM
  • intermediate monocyte: 0.2 nTPM
  • NK-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM

Brain region

  • white matter: 6 nTPM
  • choroid plexus: 5.1 nTPM
  • basal ganglia: 5 nTPM
  • cerebellum: 4.7 nTPM
  • spinal cord: 4.7 nTPM
  • medulla oblongata: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.35
gnomAD pLI
0
gnomAD missense Z
0.21
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAOX as an antibody target. Whether an autoantibody or antibody against PAOX could matter depends on whether native PAOX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAOX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAOX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PAOX. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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