Seroatlas · Human Serome Atlas

PANX3

Pannexin-3

Also known as: PANX3_HUMAN, Px3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96QZ0
Gene: PANX3
Ensembl: ENSG00000154143
Chromosome: 11
Canonical length: 392 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene belongs to the innexin family. Innexin family members are known to be the structural components of gap junctions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q96QZ0|PANX3
     1  MSLAHTAAEY MLSDALLPDR RGPRLKGLRL ELPLDRIVKF VAVGSPLLLM SLAFAQEFSS
    61  GSPISCFSPS NFSIRQAAYV DSSCWDSLLH HKQDGPGQDK MKSLWPHKAL PYSLLALALL
   121  MYLPVLLWQY AAVPALSSDL LFIISELDKS YNRSIRLVQH MLKIRQKSSD PYVFWNELEK
   181  ARKERYFEFP LLERYLACKQ RSHSLVATYL LRNSLLLIFT SATYLYLGHF HLDVFFQEEF
   241  SCSIKTGLLS DETHVPNLIT CRLTSLSIFQ IVSLSSVAIY TILVPVIIYN LTRLCRWDKR
   301  LLSVYEMLPA FDLLSRKMLG CPINDLNVIL LFLRANISEL ISFSWLSVLC VLKDTTTQKH
   361  NIDTVVDFMT LLAGLEPSKP KHLTNSACDE HP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PANX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 0.2 nTPM
salivary gland: 0.2 nTPM
testis: 0.2 nTPM
hypothalamus: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

other brain neurons: 4 nCPM
undifferentiated spermatogonia: 1.4 nCPM
pdcs: 0.6 nCPM
salivary acinar cells: 0.6 nCPM
brain inhibitory neurons: 0.5 nCPM
late primary spermatocytes: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2 nTPM
hypothalamus: 1.2 nTPM
basal ganglia: 0.7 nTPM
white matter: 0.6 nTPM
thalamus: 0.5 nTPM
midbrain: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PANX3 as an antibody target. Whether an autoantibody or antibody against PANX3 could matter depends on whether native PANX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PANX3 is annotated at the cell surface, where native PANX3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PANX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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