Seroatlas · Human Serome Atlas

PANX2

Pannexin-2

Also known as: hPANX2, PANX2_HUMAN, PX2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96RD6
Gene
PANX2
Ensembl
ENSG00000073150
Chromosome
22
Canonical length
677 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

677 residues, UniProt reviewed canonical sequence.

>Q96RD6|PANX2
     1  MHHLLEQSAD MATALLAGEK LRELILPGAQ DDKAGALAAL LLQLKLELPF DRVVTIGTVL
    61  VPILLVTLVF TKNFAEEPIY CYTPHNFTRD QALYARGYCW TELRDALPGV DASLWPSLFE
   121  HKFLPYALLA FAAIMYVPAL GWEFLASTRL TSELNFLLQE IDNCYHRAAE GRAPKIEKQI
   181  QSKGPGITER EKREIIENAE KEKSPEQNLF EKYLERRGRS NFLAKLYLAR HVLILLLSAV
   241  PISYLCTYYA TQKQNEFTCA LGASPDGAAG AGPAVRVSCK LPSVQLQRII AGVDIVLLCV
   301  MNLIILVNLI HLFIFRKSNF IFDKLHKVGI KTRRQWRRSQ FCDINILAMF CNENRDHIKS
   361  LNRLDFITNE SDLMYDNVVR QLLAALAQSN HDATPTVRDS GVQTVDPSAN PAEPDGAAEP
   421  PVVKRPRKKM KWIPTSNPLP QPFKEPLAIM RVENSKAEKP KPARRKTATD TLIAPLLDRS
   481  AHHYKGGGGD PGPGPAPAPA PPPAPDKKHA RHFSLDVHPY ILGTKKAKAE AVPAALPASR
   541  SQEGGFLSQA EDCGLGLAPA PIKDAPLPEK EIPYPTEPAR AGLPSGGPFH VRSPPAAPAV
   601  APLTPASLGK AEPLTILSRN ATHPLLHINT LYEAREEEDG GPRLPQDVGD LIAIPAPQQI
   661  LIATFDEPRT VVSTVEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PANX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 39 nTPM
  • cerebral cortex: 39 nTPM
  • hippocampal formation: 25 nTPM
  • midbrain: 22 nTPM
  • amygdala: 18 nTPM
  • hypothalamus: 15 nTPM

Single-cell type

  • bergmann glia: 43 nCPM
  • lactotrophs: 37 nCPM
  • other brain neurons: 37 nCPM
  • brain excitatory neurons: 36 nCPM
  • neutrophils: 32 nCPM
  • brain inhibitory neurons: 27 nCPM

Immune cell

  • neutrophil: 2 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • eosinophil: 0.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • pons: 131 nTPM
  • cerebral cortex: 107 nTPM
  • medulla oblongata: 91 nTPM
  • white matter: 57 nTPM
  • thalamus: 53 nTPM
  • hypothalamus: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
3.35
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PANX2 as an antibody target. Whether an autoantibody or antibody against PANX2 could matter depends on whether native PANX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PANX2 is annotated at the cell surface, where native PANX2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PANX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PANX2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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