Seroatlas · Human Serome Atlas

PANX1

Pannexin-1

Also known as: MRS1, PANX1_HUMAN, PX1, UNQ2529

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96RD7
Gene
PANX1
Ensembl
ENSG00000110218
Chromosome
11
Canonical length
426 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q96RD7|PANX1
     1  MAIAQLATEY VFSDFLLKEP TEPKFKGLRL ELAVDKMVTC IAVGLPLLLI SLAFAQEISI
    61  GTQISCFSPS SFSWRQAAFV DSYCWAAVQQ KNSLQSESGN LPLWLHKFFP YILLLFAILL
   121  YLPPLFWRFA AAPHICSDLK FIMEELDKVY NRAIKAAKSA RDLDMRDGAC SVPGVTENLG
   181  QSLWEVSESH FKYPIVEQYL KTKKNSNNLI IKYISCRLLT LIIILLACIY LGYYFSLSSL
   241  SDEFVCSIKS GILRNDSTVP DQFQCKLIAV GIFQLLSVIN LVVYVLLAPV VVYTLFVPFR
   301  QKTDVLKVYE ILPTFDVLHF KSEGYNDLSL YNLFLEENIS EVKSYKCLKV LENIKSSGQG
   361  IDPMLLLTNL GMIKMDVVDG KTPMSAEMRE EQGNQTAELQ GMNIDSETKA NNGEKNARQR
   421  LLDSSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PANX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 20 nTPM
  • skeletal muscle: 19 nTPM
  • liver: 16 nTPM
  • smooth muscle: 12 nTPM
  • appendix: 11 nTPM
  • gallbladder: 11 nTPM

Single-cell type

  • basal keratinocytes: 129 nCPM
  • platelets: 89 nCPM
  • suprabasal keratinocytes: 77 nCPM
  • thymic myoid cells: 53 nCPM
  • hofbauer cells: 53 nCPM
  • extravillous trophoblasts: 51 nCPM

Immune cell

  • classical monocyte: 4 nTPM
  • basophil: 3.2 nTPM
  • total PBMC: 3.2 nTPM
  • T-reg: 2.9 nTPM
  • myeloid DC: 2.7 nTPM
  • NK-cell: 2.6 nTPM

Brain region

  • hypothalamus: 22 nTPM
  • cerebral cortex: 18 nTPM
  • basal ganglia: 18 nTPM
  • pons: 14 nTPM
  • thalamus: 14 nTPM
  • midbrain: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PANX1.

Disease | AllUniProt

Conditions PANX1 is implicated in, by any mechanism.

  • Oocyte/zygote/embryo maturation arrest 7 (OZEMA7) MIM:618550

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 114 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Oocyte maturation defect 7

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
-0.42
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PANX1 as an antibody target. Whether an autoantibody or antibody against PANX1 could matter depends on whether native PANX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PANX1 is annotated at the cell surface, where native PANX1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PANX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PANX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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