PANO1
Proapoptotic nucleolar protein 1
Also known as: PANO, PANO1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- I0J062
- Gene
- PANO1
- Ensembl
- ENSG00000288675
- Chromosome
- 11
- Canonical length
- 215 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of apoptotic process; and regulation of protein stability. Located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
215 residues, UniProt reviewed canonical sequence.
>I0J062|PANO1
1 MGVRLRVWPA APHSISRCPR PLGAVLSILL AGGSRKGTPT ARCLGQRTKE KRVGGRSLRS
61 EAGSGPCPTA GAQPTAPSSA WPPRLRPRTC PQMSGELPRV RPTRVGLSSL GSGPGHPPSG
121 TRMCGERARN RRGRARRLTP EQPRIGASAG PGPPLPPARP RCSGSCHLPR PPQHLSPPQP
181 GRVRMGAAEG SRRADTHHAR RRRRARLPAP RSASTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PANO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.75
- Highest tissue expression
- 3.4 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 3.4 nTPM
- pancreas: 3.2 nTPM
- pituitary gland: 2.6 nTPM
- testis: 2.1 nTPM
- liver: 1.7 nTPM
- cerebral cortex: 1.5 nTPM
Single-cell type
- early spermatids: 16 nCPM
- retinal horizontal cells: 8 nCPM
- hepatic stellate cells: 6.5 nCPM
- retinal bipolar cells: 5.9 nCPM
- lactotrophs: 4.9 nCPM
- cone photoreceptor cells: 4.1 nCPM
Immune cell
- neutrophil: 0.9 nTPM
- basophil: 0.8 nTPM
- NK-cell: 0.5 nTPM
- naive CD8 T-cell: 0.3 nTPM
- classical monocyte: 0.1 nTPM
- gdT-cell: 0.1 nTPM
Brain region
- cerebellum: 12 nTPM
- cerebral cortex: 8.7 nTPM
- hippocampal formation: 7.9 nTPM
- hypothalamus: 7.6 nTPM
- amygdala: 7.3 nTPM
- basal ganglia: 7.3 nTPM
OntologyGO
Biological processes
- apoptotic process
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of apoptotic process
- regulation of protein stability
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PANO1 as an antibody target. Whether an autoantibody or antibody against PANO1 could matter depends on whether native PANO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PANO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PANO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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