Seroatlas · Human Serome Atlas

PALMD

Palmdelphin

Also known as: C1orf11, FLJ20271, PALMD_HUMAN, PALML

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NP74
Gene
PALMD
Ensembl
ENSG00000099260
Chromosome
1
Canonical length
551 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments,Focal adhesion sites

OverviewNCBI Gene

Predicted to be involved in regulation of cell shape. Predicted to be located in dendritic spine and membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>Q9NP74|PALMD
     1  MEEAELVKGR LQAITDKRKI QEEISQKRLK IEEDKLKHQH LKKKALREKW LLDGISSGKE
    61  QEEMKKQNQQ DQHQIQVLEQ SILRLEKEIQ DLEKAELQIS TKEEAILKKL KSIERTTEDI
   121  IRSVKVEREE RAEESIEDIY ANIPDLPKSY IPSRLRKEIN EEKEDDEQNR KALYAMEIKV
   181  EKDLKTGEST VLSSIPLPSD DFKGTGIKVY DDGQKSVYAV SSNHSAAYNG TDGLAPVEVE
   241  ELLRQASERN SKSPTEYHEP VYANPFYRPT TPQRETVTPG PNFQERIKIK TNGLGIGVNE
   301  SIHNMGNGLS EERGNNFNHI SPIPPVPHPR SVIQQAEEKL HTPQKRLMTP WEESNVMQDK
   361  DAPSPKPRLS PRETIFGKSE HQNSSPTCQE DEEDVRYNIV HSLPPDINDT EPVTMIFMGY
   421  QQAEDSEEDK KFLTGYDGII HAELVVIDDE EEEDEGEAEK PSYHPIAPHS QVYQPAKPTP
   481  LPRKRSEASP HENTNHKSPH KNSISLKEQE ESLGSPVHHS PFDAQTTGDG TEDPSLTALR
   541  MRMAKLGKKV I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PALMD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
123 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 123 nTPM
  • skeletal muscle: 106 nTPM
  • heart muscle: 83 nTPM
  • breast: 74 nTPM
  • salivary gland: 67 nTPM
  • choroid plexus: 65 nTPM

Single-cell type

  • adipocytes: 663 nCPM
  • lacrimal acinar cells: 471 nCPM
  • myonuclei: 462 nCPM
  • vascular endothelial cells: 426 nCPM
  • choroid plexus epithelial cells: 390 nCPM
  • adrenal cortex cells: 333 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 85 nTPM
  • amygdala: 16 nTPM
  • hypothalamus: 15 nTPM
  • hippocampal formation: 14 nTPM
  • cerebral cortex: 11 nTPM
  • thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
-0.17
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PALMD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PALMD as an antibody target. Whether an autoantibody or antibody against PALMD could matter depends on whether native PALMD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PALMD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PALMD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PALMD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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