Seroatlas · Human Serome Atlas

PALM2AKAP2

PALM2-AKAP2 fusion protein

Also known as: PALM2-AKAP2, PLAK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2D5
Gene
PALM2AKAP2
Ensembl
ENSG00000157654
Chromosome
9
Canonical length
1103 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene belongs to the paralemmin downstream gene (PDG) family defined in PMID:22855693. Paralemmin downstream genes may have evolved contiguously with the paralemmin genes and are associated with other paralemmin paralogs in humans and several other taxa. The gene encodes three distinct protein isoforms, the PALM2 isoform, the AKAP2 isoform and the PALM2-AKAP2 isoform. The biological significance of the PALM2-AKAP2 isoforms is yet unknown. Earlier, PALM2 and AKAP2 were annotated as separate genes and PALM2-AKAP2 was annotated as a readthrough gene. [provided by RefSeq, May 2019]

Canonical amino-acid sequenceUniProt

1103 residues, UniProt reviewed canonical sequence.

>Q9Y2D5|PALM2AKAP2
     1  MAEAELHKER LQAIAEKRKR QTEIEGKRQQ LDEQILLLQH SKSKVLREKW LLQGIPAGTA
    61  EEEEARRRQS EEDEFRVKQL EDNIQRLEQE IQTLESEESQ ISAKEQIILE KLKETEKSFK
   121  DFQKGFSSTD GDAVNYISSQ LPDLPILCSR TAEPSPGQDG TSRAAGVGWE NVLLKEGESA
   181  SNATETSGPD MTIKKPPQLS EDDIWLKSEG DNYSATLLEP AASSLSPDHK NMEIEVSVAE
   241  CKSVPGITST PHPMDHPSAF YSPPHNGLLT DHHESLDNDV AREIRYLDEV LEANCCDSAV
   301  DGTYNGTSSP EPGAVVLVGG LSPPVHEATQ PEPTERTASR QAPPHIELSN SSPDPMAEAE
   361  RTNGHSPSQP RDALGDSLQV PVSPSSTTSS RCSSRDGEFT LTTLKKEAKF ELRAFHEDKK
   421  PSKLFEDDEH EKEQYCIRKV RPSEEMLELE KERRELIRSQ AVKKNPGIAA KWWNPPQEKT
   481  IEEQLDEEHL ESHKKYKERK ERRAQQEQLL LQKQLQQQQQ QPPSQLCTAP ASSHERASMI
   541  DKAKEDIVTE QIDFSAARKQ FQLMENSRQA VAKGQSTPRL FSIKPFYRPL GSVNSDKPLT
   601  NPRPPSVGGP PEDSGASAAK GQKSPGALET PSAAGSQGNT ASQGKEGPYS EPSKRGPLSK
   661  LWAEDGEFTS ARAVLTVVKD DDHGILDQFS RSVNVSLTQE ELDSGLDELS VRSQDTTVLE
   721  TLSNDFSMDN ISDSGASNET TNALQENSLA DFSLPQTPQT DNPSEGRGEG VSKSFSDHGF
   781  YSPSSTLGDS PLVDDPLEYQ AGLLVQNAIQ QAIAEQVDKA VSKTSRDGAE QQGPEATVEE
   841  AEAAAFGSEK PQSMFEPPQV SSPVQEKRDV LPKILPAEDR ALRERGPPQP LPAVQPSGPI
   901  NMEETRPEGS YFSKYSEAAE LRSTASLLAT QESDVMVGPF KLRSRKQRTL SMIEEEIRAA
   961  QEREEELKRQ RQVLQSTQSP RTKNAPSLPS RTCYKTAPGK IEKVKPPPSP TTEGPSLQPD
  1021  LAPEEAAGTQ RPKNLMQTLM EDYETHKSKR RERMDDSSYT SKLLSCKVTS EVLEATRVNR
  1081  RKSALALRWE AGIYANQEEE DNE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PALM2AKAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 92 nTPM
  • adipose tissue: 91 nTPM
  • heart muscle: 88 nTPM
  • lung: 65 nTPM
  • blood vessel: 57 nTPM
  • breast: 48 nTPM

Single-cell type

  • oligodendrocytes: 987 nCPM
  • adipocytes: 917 nCPM
  • mast cells: 682 nCPM
  • vascular endothelial cells: 648 nCPM
  • alveolar cells type 1: 486 nCPM
  • ependymal cells: 455 nCPM

Immune cell

  • memory B-cell: 11 nTPM
  • naive B-cell: 10 nTPM
  • T-reg: 3.9 nTPM
  • basophil: 3 nTPM
  • plasmacytoid DC: 2.4 nTPM
  • NK-cell: 2.2 nTPM

Brain region

  • thalamus: 113 nTPM
  • cerebral cortex: 90 nTPM
  • midbrain: 89 nTPM
  • white matter: 86 nTPM
  • amygdala: 78 nTPM
  • basal ganglia: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PALM2AKAP2 as an antibody target. Whether an autoantibody or antibody against PALM2AKAP2 could matter depends on whether native PALM2AKAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PALM2AKAP2 is annotated at the cell surface, where native PALM2AKAP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PALM2AKAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PALM2AKAP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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