PAK6-AS1
Putative uncharacterized protein PAK6-AS1
Also known as: CO056_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for PAK6-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
161 residues, UniProt reviewed canonical sequence.
>Q8N910|PAK6-AS1
1 MPRAGRAPAE GGPAPGTRSS RCLRPRPLAW RRLVPNFGAW APRKGAARVG RPVLSPRTSG
61 AAGEPTCGAG SPGTLEEGVA SGRTRRRTQS AGEVAKCRWG LGQEPLCPRG AVLLNSFSPP
121 AWPQFPPALR LRALAWPQPR GPACGSTAQW PPRGDPTWRI SLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PAK6-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.72
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PAK6-AS1 as an antibody target. Whether an autoantibody or antibody against PAK6-AS1 could matter depends on whether native PAK6-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PAK6-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PAK6-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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