Seroatlas · Human Serome Atlas

PAGE5

P antigen family member 5

Also known as: CT16.1, CT16.2, PAGE-5, PAGE5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GU1
Gene: PAGE5
Ensembl: ENSG00000158639
Chromosome: X
Canonical length: 130 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

This gene is a member of family of proteins that are expressed in a variety of tumors and in some fetal and reproductive tissues. The encoded protein may protect cells from programmed cell death. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>Q96GU1|PAGE5
     1  MQAPWAGNRG WAGTREEVRD MSEHVTRSQS SERGNDQESS QPVGPVIVQQ PTEEKRQEEE
    61  PPTDNQGIAP SGEIKNEGAP AVQGTDVEAF QQELALLKIE DAPGDGPDVR EGTLPTFDPT
   121  KVLEAGEGQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAGE5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

testis: 26 nTPM
liver: 1 nTPM
fallopian tube: 0.3 nTPM
stomach: 0.3 nTPM
tonsil: 0.3 nTPM
gallbladder: 0.2 nTPM

Single-cell type

early primary spermatocytes: 170 nCPM
undifferentiated spermatogonia: 122 nCPM
differentiating spermatogonia: 113 nCPM
late primary spermatocytes: 21 nCPM
early spermatids: 15 nCPM
late spermatids: 7.1 nCPM

Immune cell

MAIT T-cell: 1.9 nTPM
memory CD4 T-cell: 1.6 nTPM
T-reg: 1.5 nTPM
memory CD8 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.5 nTPM
gdT-cell: 0.3 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0.02
gnomAD missense Z: 0.39
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAGE5 as an antibody target. Whether an autoantibody or antibody against PAGE5 could matter depends on whether native PAGE5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAGE5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAGE5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...