PAGE3
P antigen family member 3
Also known as: CT16.6, GAGED1, PAGE-3, PAGE3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5JUK9
- Gene
- PAGE3
- Ensembl
- ENSG00000204279
- Chromosome
- X
- Canonical length
- 113 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear speckles
OverviewNCBI Gene
This gene is a member of family of proteins that are expressed in a variety of tumors and in some fetal and reproductive tissues. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2015]
Canonical amino-acid sequenceUniProt
113 residues, UniProt reviewed canonical sequence.
>Q5JUK9|PAGE3
1 MSGHQRTRSR SRERRDDQDS NHPVGAVVAQ ELPSNDQLQQ EEPPIESQDY TPGQERDEGA
61 LDFQVLGLAA YLWELTRSKT GGERGDGPNV KGEFLPNLEP VKIPEAGEGQ PSVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PAGE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.66
- Highest tissue expression
- 7.2 nTPM
Expression across tissuesHPA
Tissue
- testis: 7.2 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 430 nCPM
- early spermatids: 125 nCPM
- late primary spermatocytes: 24 nCPM
- early primary spermatocytes: 2.6 nCPM
- undifferentiated spermatogonia: 1 nCPM
- leydig cells: 0.8 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 0.3 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.8
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.65
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PAGE3 as an antibody target. Whether an autoantibody or antibody against PAGE3 could matter depends on whether native PAGE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PAGE3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PAGE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...