Seroatlas · Human Serome Atlas

PAGE2

P antigen family member 2

Also known as: CT16.4, GAGEC2, MGC62094, PAGE-2, PAGE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z2X7
Gene
PAGE2
Ensembl
ENSG00000234068
Chromosome
X
Canonical length
111 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PAGE2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

111 residues, UniProt reviewed canonical sequence.

>Q7Z2X7|PAGE2
     1  MSELLRARSQ SSERGNDQES SQPVGSVIVQ EPTEEKRQEE EPPTDNQGIA PSGEIENQAV
    61  PAFQGPDMEA FQQELALLKI EDEPGDGPDV REGIMPTFDL TKVLEAGDAQ P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAGE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • testis: 28 nTPM
  • placenta: 0.6 nTPM
  • skin: 0.5 nTPM
  • spleen: 0.3 nTPM
  • adipose tissue: 0.2 nTPM
  • cerebellum: 0.2 nTPM

Single-cell type

  • early primary spermatocytes: 196 nCPM
  • differentiating spermatogonia: 178 nCPM
  • undifferentiated spermatogonia: 149 nCPM
  • late primary spermatocytes: 13 nCPM
  • syncytiotrophoblasts: 7.1 nCPM
  • early spermatids: 6.9 nCPM

Immune cell

  • naive CD4 T-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.4 nTPM
  • white matter: 0.4 nTPM
  • amygdala: 0.2 nTPM
  • basal ganglia: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0.06
gnomAD missense Z
-0.44
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAGE2 as an antibody target. Whether an autoantibody or antibody against PAGE2 could matter depends on whether native PAGE2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAGE2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAGE2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PAGE2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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