Seroatlas · Human Serome Atlas

PAFAH2

Platelet-activating factor acetylhydrolase 2, cytoplasmic

Also known as: HSD-PLA2, PAFA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99487
Gene
PAFAH2
Ensembl
ENSG00000158006
Chromosome
1
Canonical length
392 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q99487|PAFAH2
     1  MGVNQSVGFP PVTGPHLVGC GDVMEGQNLQ GSFFRLFYPC QKAEETMEQP LWIPRYEYCT
    61  GLAEYLQFNK RCGGLLFNLA VGSCRLPVSW NGPFKTKDSG YPLIIFSHGL GAFRTLYSAF
   121  CMELASRGFV VAVPEHRDRS AATTYFCKQA PEENQPTNES LQEEWIPFRR VEEGEKEFHV
   181  RNPQVHQRVS ECLRVLKILQ EVTAGQTVFN ILPGGLDLMT LKGNIDMSRV AVMGHSFGGA
   241  TAILALAKET QFRCAVALDA WMFPLERDFY PKARGPVFFI NTEKFQTMES VNLMKKICAQ
   301  HEQSRIITVL GSVHRSQTDF AFVTGNLIGK FFSTETRGSL DPYEGQEVMV RAMLAFLQKH
   361  LDLKEDYNQW NNLIEGIGPS LTPGAPHHLS SL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAFAH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 45 nTPM
  • pancreas: 30 nTPM
  • parathyroid gland: 22 nTPM
  • kidney: 18 nTPM
  • small intestine: 18 nTPM
  • liver: 17 nTPM

Single-cell type

  • pdcs: 51 nCPM
  • parietal cells: 50 nCPM
  • enterocytes: 45 nCPM
  • adrenal medulla cells: 43 nCPM
  • nk-cells: 37 nCPM
  • colonocytes: 33 nCPM

Immune cell

  • eosinophil: 60 nTPM
  • plasmacytoid DC: 39 nTPM
  • basophil: 36 nTPM
  • gdT-cell: 24 nTPM
  • NK-cell: 17 nTPM
  • memory CD8 T-cell: 15 nTPM

Brain region

  • white matter: 16 nTPM
  • choroid plexus: 14 nTPM
  • midbrain: 13 nTPM
  • medulla oblongata: 13 nTPM
  • thalamus: 13 nTPM
  • basal ganglia: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PAFAH2.

Disease | ImmuneIEDB

Conditions an epitope on PAFAH2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.11
gnomAD pLI
0
gnomAD missense Z
-0.12
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAFAH2 as an antibody target. Whether an autoantibody or antibody against PAFAH2 could matter depends on whether native PAFAH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAFAH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAFAH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PAFAH2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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