Seroatlas · Human Serome Atlas

PAFAH1B2

Platelet-activating factor acetylhydrolase IB subunit alpha2

Also known as: PA1B2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P68402
Gene: PAFAH1B2
Ensembl: ENSG00000168092
Chromosome: 11
Canonical length: 229 aa
Protein class: Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoli,Plasma membrane,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>P68402|PAFAH1B2
     1  MSQGDSNPAA IPHAAEDIQG DDRWMSQHNR FVLDCKDKEP DVLFVGDSMV QLMQQYEIWR
    61  ELFSPLHALN FGIGGDTTRH VLWRLKNGEL ENIKPKVIVV WVGTNNHENT AEEVAGGIEA
   121  IVQLINTRQP QAKIIVLGLL PRGEKPNPLR QKNAKVNQLL KVSLPKLANV QLLDTDGGFV
   181  HSDGAISCHD MFDFLHLTGG GYAKICKPLH ELIMQLLEET PEEKQTTIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAFAH1B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 54 nTPM
cerebellum: 39 nTPM
bone marrow: 39 nTPM
cerebral cortex: 38 nTPM
midbrain: 37 nTPM
hypothalamus: 34 nTPM

Single-cell type

neutrophils: 244 nCPM
extravillous trophoblasts: 146 nCPM
neutrophil progenitors: 139 nCPM
basal keratinocytes: 137 nCPM
monocytes: 113 nCPM
endometrial glandular cells: 112 nCPM

Immune cell

non-classical monocyte: 66 nTPM
neutrophil: 64 nTPM
basophil: 64 nTPM
intermediate monocyte: 59 nTPM
total PBMC: 53 nTPM
classical monocyte: 51 nTPM

Brain region

white matter: 103 nTPM
pons: 102 nTPM
spinal cord: 100 nTPM
medulla oblongata: 94 nTPM
midbrain: 93 nTPM
hypothalamus: 92 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.93
gnomAD missense Z: 1.65
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PAFAH1B2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAFAH1B2 as an antibody target. Whether an autoantibody or antibody against PAFAH1B2 could matter depends on whether native PAFAH1B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAFAH1B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PAFAH1B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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