Seroatlas · Human Serome Atlas

PAEP

Glycodelin

Also known as: GD, GdA, GdF, GdS, MGC138509, MGC142288, PAEG, PAEP_HUMAN, PEP, PP14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P09466
Gene: PAEP
Ensembl: ENSG00000122133
Chromosome: 9
Canonical length: 180 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in female reproductive system
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>P09466|PAEP
     1  MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKLAGTWHSM AMATNNISLM ATLKAPLRVH
    61  ITSLLPTPED NLEIVLHRWE NNSCVEKKVL GEKTENPKKF KINYTVANEA TLLDTDYDNF
   121  LFLCLQDTTT PIQSMMCQYL ARVLVEDDEI MQGFIRAFRP LPRHLWYLLD LKQMEEPCRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAEP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 241 nTPM

Expression across tissuesHPA

Tissue

endometrium: 241 nTPM
cervix: 45 nTPM
seminal vesicle: 42 nTPM
placenta: 26 nTPM
fallopian tube: 7.7 nTPM
stomach: 5.6 nTPM

Single-cell type

endometrial glandular cells: 17,493 nCPM
endometrial stromal cells: 584 nCPM
endometrial ciliated cells: 516 nCPM
pdcs: 215 nCPM
b-cells: 111 nCPM
innate lymphoid cells: 92 nCPM

Immune cell

basophil: 3.1 nTPM
neutrophil: 1.4 nTPM
naive B-cell: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM

Brain region

white matter: 5.3 nTPM
cerebellum: 4.6 nTPM
cerebral cortex: 4.5 nTPM
choroid plexus: 4.3 nTPM
hippocampal formation: 4.2 nTPM
thalamus: 4.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PAEP.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 43 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Kleefstra syndrome 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PAEP as an antibody target. Whether an autoantibody or antibody against PAEP could matter depends on whether native PAEP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PAEP is annotated as secreted, so native PAEP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PAEP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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