Seroatlas · Human Serome Atlas

PACC1

Proton-activated chloride channel

Also known as: ASOR, C1orf75, FLJ10874, PAC, PACC1_HUMAN, PAORAC, TMEM206

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H813
Gene: PACC1
Ensembl: ENSG00000065600
Chromosome: 1
Canonical length: 350 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables pH-gated chloride channel activity. Involved in chloride transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q9H813|PACC1
     1  MIRQERSTSY QELSEELVQV VENSELADEQ DKETVRVQGP GILPGLDSES ASSSIRFSKA
    61  CLKNVFSVLL IFIYLLLMAV AVFLVYRTIT DFREKLKHPV MSVSYKEVDR YDAPGIALYP
   121  GQAQLLSCKH HYEVIPPLTS PGQPGDMNCT TQRINYTDPF SNQTVKSALI VQGPREVKKR
   181  ELVFLQFRLN KSSEDFSAID YLLFSSFQEF LQSPNRVGFM QACESAYSSW KFSGGFRTWV
   241  KMSLVKTKEE DGREAVEFRQ ETSVVNYIDQ RPAAKKSAQL FFVVFEWKDP FIQKVQDIVT
   301  ANPWNTIALL CGAFLALFKA AEFAKLSIKW MIKIRKRYLK RRGQATSHIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PACC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 70 nTPM
midbrain: 27 nTPM
hippocampal formation: 19 nTPM
basal ganglia: 15 nTPM
hypothalamus: 15 nTPM
cerebral cortex: 14 nTPM

Single-cell type

oligodendrocytes: 99 nCPM
oligodendrocyte progenitor cells: 48 nCPM
early primary spermatocytes: 44 nCPM
hofbauer cells: 42 nCPM
thymocytes: 39 nCPM
müller glia: 35 nCPM

Immune cell

basophil: 21 nTPM
plasmacytoid DC: 20 nTPM
myeloid DC: 14 nTPM
intermediate monocyte: 12 nTPM
non-classical monocyte: 11 nTPM
classical monocyte: 8.7 nTPM

Brain region

white matter: 56 nTPM
medulla oblongata: 40 nTPM
cerebellum: 36 nTPM
basal ganglia: 35 nTPM
spinal cord: 33 nTPM
pons: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chloride transport

Molecular functions

pH-gated chloride channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

TMEM206 protein
TMEM206 protein family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PACC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TMEM147

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PACC1 as an antibody target. Whether an autoantibody or antibody against PACC1 could matter depends on whether native PACC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PACC1 is annotated at the cell surface, where native PACC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PACC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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