Seroatlas · Human Serome Atlas

PABIR3

PABIR family member 1

Also known as: FAM122C, PBIR3_HUMAN, RP3-473B4.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P4D5
Gene: PABIR3
Ensembl: ENSG00000156500
Chromosome: X
Canonical length: 195 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable protein serine/threonine phosphatase inhibitor activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q6P4D5|PABIR3
     1  MAQEKMKLGF KSLPSSTTAD GNILRRVNSA PLINGLGFNS QVLQADMLRI RTNRTTFRNR
    61  RSLLLPPPPF HGSISRLHQI KQEEAMDLIN RETMSEWKLQ SEIQISHSWE EGLKLVKWHF
   121  NINQKRFSKA QPTCFLLILP NCQKIMCIYF QLLLMETTAM LDLLVIRQLK SALSQTLLCH
   181  LLILVLICSS RQTFN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PABIR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

ovary: 10 nTPM
choroid plexus: 6.9 nTPM
bone marrow: 5.7 nTPM
testis: 5.6 nTPM
retina: 5.2 nTPM
thymus: 4 nTPM

Single-cell type

sertoli cells: 152 nCPM
granulosa cells: 112 nCPM
ependymal cells: 108 nCPM
choroid plexus epithelial cells: 98 nCPM
tuft cells: 81 nCPM
early spermatids: 68 nCPM

Immune cell

eosinophil: 3.4 nTPM
plasmacytoid DC: 3.3 nTPM
non-classical monocyte: 3 nTPM
memory B-cell: 2.3 nTPM
NK-cell: 2.1 nTPM
neutrophil: 2 nTPM

Brain region

choroid plexus: 15 nTPM
cerebral cortex: 12 nTPM
white matter: 11 nTPM
cerebellum: 10 nTPM
hypothalamus: 9.3 nTPM
medulla oblongata: 9.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PABIR3.

Disease | ImmuneIEDB

Conditions an epitope on PABIR3 was assayed in.

viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein serine/threonine phosphatase inhibitor activity

Protein domainsUniProt · Pfam · InterPro

PABIR1/2/3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PABIR3 as an antibody target. Whether an autoantibody or antibody against PABIR3 could matter depends on whether native PABIR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PABIR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PABIR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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