Seroatlas · Human Serome Atlas

P3R3URF

PIK3R3 upstream open reading frame protein

Also known as: P3URF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A087WWA1
Gene
P3R3URF
Ensembl
ENSG00000250719
Chromosome
1
Canonical length
95 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cytokine-mediated signaling pathway. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

95 residues, UniProt reviewed canonical sequence.

>A0A087WWA1|P3R3URF
     1  MGPSRLVRGP RPQGMRSPYR RPGMGWPRPR FPRMFKCSRR RYQQGLRGRT ASSAAINPAT
    61  RAMGINNTHT DTTIVWIFPP QVLRHLRQPG IFLIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P3R3URF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
134 nTPM

Expression across tissuesHPA

Tissue

  • testis: 134 nTPM
  • prostate: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late spermatids: 6,211 nCPM
  • early spermatids: 669 nCPM
  • late primary spermatocytes: 31 nCPM
  • sertoli cells: 5.9 nCPM
  • peritubular myoid cells: 5.8 nCPM
  • undifferentiated spermatogonia: 3.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 3.7 nTPM
  • cerebral cortex: 1.4 nTPM
  • pons: 0.6 nTPM
  • choroid plexus: 0.5 nTPM
  • white matter: 0.5 nTPM
  • hippocampal formation: 0.3 nTPM

OntologyGO

Biological processes

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P3R3URF as an antibody target. Whether an autoantibody or antibody against P3R3URF could matter depends on whether native P3R3URF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P3R3URF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label P3R3URF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/P3R3URF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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