Seroatlas · Human Serome Atlas

P2RY8

S-geranylgeranyl-glutathione receptor P2RY8

Also known as: P2RY8_HUMAN, P2Y8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VZ1
Gene: P2RY8
Ensembl: ENSG00000182162
Chromosome: X
Canonical length: 359 aa
Protein class: Cancer-related genes, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q86VZ1|P2RY8
     1  MQVPNSTGPD NATLQMLRNP AIAVALPVVY SLVAAVSIPG NLFSLWVLCR RMGPRSPSVI
    61  FMINLSVTDL MLASVLPFQI YYHCNRHHWV FGVLLCNVVT VAFYANMYSS ILTMTCISVE
   121  RFLGVLYPLS SKRWRRRRYA VAACAGTWLL LLTALSPLAR TDLTYPVHAL GIITCFDVLK
   181  WTMLPSVAMW AVFLFTIFIL LFLIPFVITV ACYTATILKL LRTEEAHGRE QRRRAVGLAA
   241  VVLLAFVTCF APNNFVLLAH IVSRLFYGKS YYHVYKLTLC LSCLNNCLDP FVYYFASREF
   301  QLRLREYLGC RRVPRDTLDT RRESLFSART TSVRSEAGAH PEGMEGATRP GLQRQESVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RY8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

lymph node: 37 nTPM
tonsil: 31 nTPM
bone marrow: 29 nTPM
spleen: 19 nTPM
appendix: 18 nTPM
thymus: 15 nTPM

Single-cell type

hematopoietic stem cells: 326 nCPM
neutrophils: 322 nCPM
b-cells: 308 nCPM
innate lymphoid cells: 262 nCPM
neutrophil progenitors: 256 nCPM
t-cells: 222 nCPM

Immune cell

gdT-cell: 59 nTPM
memory CD8 T-cell: 56 nTPM
MAIT T-cell: 54 nTPM
total PBMC: 53 nTPM
basophil: 50 nTPM
memory CD4 T-cell: 45 nTPM

Brain region

white matter: 6.6 nTPM
medulla oblongata: 6.2 nTPM
thalamus: 5.9 nTPM
cerebral cortex: 5.3 nTPM
choroid plexus: 4.8 nTPM
pons: 4.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about P2RY8.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 32 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Multiple myeloma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: 1.73

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
P2Y purinoceptor 8

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RY8 as an antibody target. Whether an autoantibody or antibody against P2RY8 could matter depends on whether native P2RY8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RY8 is annotated at the cell surface, where native P2RY8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RY8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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