Seroatlas · Human Serome Atlas

P2RY4

P2Y purinoceptor 4

Also known as: NRU, P2P, P2RY4_HUMAN, P2Y4, UNR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51582
Gene: P2RY4
Ensembl: ENSG00000186912
Chromosome: X
Canonical length: 365 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>P51582|P2RY4
     1  MASTESSLLR SLGLSPGPGS SEVELDCWFD EDFKFILLPV SYAVVFVLGL GLNAPTLWLF
    61  IFRLRPWDAT ATYMFHLALS DTLYVLSLPT LIYYYAAHNH WPFGTEICKF VRFLFYWNLY
   121  CSVLFLTCIS VHRYLGICHP LRALRWGRPR LAGLLCLAVW LVVAGCLVPN LFFVTTSNKG
   181  TTVLCHDTTR PEEFDHYVHF SSAVMGLLFG VPCLVTLVCY GLMARRLYQP LPGSAQSSSR
   241  LRSLRTIAVV LTVFAVCFVP FHITRTIYYL ARLLEADCRV LNIVNVVYKV TRPLASANSC
   301  LDPVLYLLTG DKYRRQLRQL CGGGKPQPRT AASSLALVSL PEDSSCRWAA TPQDSSCSTP
   361  RADRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RY4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 2.1 nTPM

Expression across tissuesHPA

Tissue

small intestine: 2.1 nTPM
skin: 0.6 nTPM
rectum: 0.4 nTPM
colon: 0.3 nTPM
cervix: 0.2 nTPM
duodenum: 0.2 nTPM

Single-cell type

goblet cells: 1.8 nCPM
basal prostatic cells: 0.3 nCPM
thyrotrophs: 0.3 nCPM
papillary tip epithelial cells: 0.2 nCPM
retinal bipolar cells: 0.2 nCPM
distal convoluted tubule cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 1.2 nTPM
choroid plexus: 1.1 nTPM
medulla oblongata: 1.1 nTPM
amygdala: 1 nTPM
basal ganglia: 0.9 nTPM
cerebral cortex: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.17
gnomAD missense Z: -0.32
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
P2Y purinoceptor 4

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RY4 as an antibody target. Whether an autoantibody or antibody against P2RY4 could matter depends on whether native P2RY4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RY4 is annotated at the cell surface, where native P2RY4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RY4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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