P2RY2

Protein identityUniProt · HPA

UniProt accession

P41231

Gene

P2RY2

Ensembl

ENSG00000175591

Chromosome

11

Canonical length

377 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins, Transporters

Subcellular location

Cytosol

OverviewNCBI Gene

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>P41231|P2RY2
     1  MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL NAVALYIFLC
    61  RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP FSTVLCKLVR FLFYTNLYCS
   121  ILFLTCISVH RCLGVLRPLR SLRWGRARYA RRVAGAVWVL VLACQAPVLY FVTTSARGGR
   181  VTCHDTSAPE LFSRFVAYSS VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK
   241  RKSVRTIAVV LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC
   301  LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE DVLGSSEDSR
   361  RTESTPAGSE NTKDIRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

47 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.91

gnomAD pLI

0.08

gnomAD missense Z

0.2

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• blood vessel diameter maintenance
• cellular response to ATP
• G protein-coupled purinergic nucleotide receptor signaling pathway
• G protein-coupled receptor signaling pathway
• intracellular monoatomic ion homeostasis
• phospholipase C-activating G protein-coupled receptor signaling pathway
• positive regulation of mucus secretion

Molecular functions

• A1 adenosine receptor binding
• G protein-coupled purinergic nucleotide receptor activity
• G protein-coupled UTP receptor activity
• signaling receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• GPCR, rhodopsin-like, 7TM
• 7 transmembrane receptor (rhodopsin family)
• P2Y2 purinoceptor

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix