P2RY14
P2Y purinoceptor 14
Also known as: GPR105, KIAA0001, P2Y14_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15391
- Gene
- P2RY14
- Ensembl
- ENSG00000174944
- Chromosome
- 3
- Canonical length
- 338 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
338 residues, UniProt reviewed canonical sequence.
>Q15391|P2RY14
1 MINSTSTQPP DESCSQNLLI TQQIIPVLYC MVFIAGILLN GVSGWIFFYV PSSKSFIIYL
61 KNIVIADFVM SLTFPFKILG DSGLGPWQLN VFVCRVSAVL FYVNMYVSIV FFGLISFDRY
121 YKIVKPLWTS FIQSVSYSKL LSVIVWMLML LLAVPNIILT NQSVREVTQI KCIELKSELG
181 RKWHKASNYI FVAIFWIVFL LLIVFYTAIT KKIFKSHLKS SRNSTSVKKK SSRNIFSIVF
241 VFFVCFVPYH IARIPYTKSQ TEAHYSCQSK EILRYMKEFT LLLSAANVCL DPIIYFFLCQ
301 PFREILCKKL HIPLKAQNDL DISRIKRGNT TLESTDTLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against P2RY14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- placenta: 30 nTPM
- choroid plexus: 20 nTPM
- esophagus: 19 nTPM
- small intestine: 11 nTPM
- colon: 11 nTPM
- stomach: 10 nTPM
Single-cell type
- pdcs: 337 nCPM
- hematopoietic stem cells: 317 nCPM
- cdc: 261 nCPM
- decidual stromal cells: 234 nCPM
- megakaryocyte progenitors: 234 nCPM
- mast cells: 178 nCPM
Immune cell
- eosinophil: 231 nTPM
- plasmacytoid DC: 98 nTPM
- MAIT T-cell: 19 nTPM
- naive B-cell: 17 nTPM
- myeloid DC: 14 nTPM
- NK-cell: 12 nTPM
Brain region
- choroid plexus: 58 nTPM
- cerebral cortex: 16 nTPM
- thalamus: 13 nTPM
- basal ganglia: 13 nTPM
- cerebellum: 12 nTPM
- white matter: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.34
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.1
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads P2RY14 as an antibody target. Whether an autoantibody or antibody against P2RY14 could matter depends on whether native P2RY14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
P2RY14 is annotated at the cell surface, where native P2RY14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label P2RY14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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