Seroatlas · Human Serome Atlas

P2RY13

P2Y purinoceptor 13

Also known as: FKSG77, GPR86, GPR94, P2Y13, P2Y13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BPV8
Gene: P2RY13
Ensembl: ENSG00000181631
Chromosome: 3
Canonical length: 354 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q9BPV8|P2RY13
     1  MTAAIRRQRE LSILPKVTLE AMNTTVMQGF NRSERCPRDT RIVQLVFPAL YTVVFLTGIL
    61  LNTLALWVFV HIPSSSTFII YLKNTLVADL IMTLMLPFKI LSDSHLAPWQ LRAFVCRFSS
   121  VIFYETMYVG IVLLGLIAFD RFLKIIRPLR NIFLKKPVFA KTVSIFIWFF LFFISLPNTI
   181  LSNKEATPSS VKKCASLKGP LGLKWHQMVN NICQFIFWTV FILMLVFYVV IAKKVYDSYR
   241  KSKSKDRKNN KKLEGKVFVV VAVFFVCFAP FHFARVPYTH SQTNNKTDCR LQNQLFIAKE
   301  TTLFLAATNI CMDPLIYIFL CKKFTEKLPC MQGRKTTASS QENHSSQTDN ITLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RY13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

spleen: 35 nTPM
bone marrow: 24 nTPM
appendix: 19 nTPM
lymph node: 17 nTPM
small intestine: 10 nTPM
tonsil: 7.9 nTPM

Single-cell type

neutrophils: 414 nCPM
microglia: 265 nCPM
kupffer cells: 261 nCPM
neutrophil progenitors: 166 nCPM
macrophages: 79 nCPM
monocytes: 55 nCPM

Immune cell

neutrophil: 583 nTPM
non-classical monocyte: 186 nTPM
intermediate monocyte: 155 nTPM
classical monocyte: 153 nTPM
eosinophil: 137 nTPM
total PBMC: 78 nTPM

Brain region

thalamus: 12 nTPM
white matter: 12 nTPM
spinal cord: 11 nTPM
medulla oblongata: 10 nTPM
choroid plexus: 8.9 nTPM
midbrain: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway

Molecular functions

G protein-coupled purinergic nucleotide receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RY13 as an antibody target. Whether an autoantibody or antibody against P2RY13 could matter depends on whether native P2RY13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RY13 is annotated at the cell surface, where native P2RY13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RY13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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