Seroatlas · Human Serome Atlas

P2RY12

P2Y purinoceptor 12

Also known as: HORK3, P2Y12, P2Y12_HUMAN, SP1999

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H244
Gene
P2RY12
Ensembl
ENSG00000169313
Chromosome
3
Canonical length
342 aa
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q9H244|P2RY12
     1  MQAVDNLTSA PGNTSLCTRD YKITQVLFPL LYTVLFFVGL ITNGLAMRIF FQIRSKSNFI
    61  IFLKNTVISD LLMILTFPFK ILSDAKLGTG PLRTFVCQVT SVIFYFTMYI SISFLGLITI
   121  DRYQKTTRPF KTSNPKNLLG AKILSVVIWA FMFLLSLPNM ILTNRQPRDK NVKKCSFLKS
   181  EFGLVWHEIV NYICQVIFWI NFLIVIVCYT LITKELYRSY VRTRGVGKVP RKKVNVKVFI
   241  IIAVFFICFV PFHFARIPYT LSQTRDVFDC TAENTLFYVK ESTLWLTSLN ACLDPFIYFF
   301  LCKSFRNSLI SMLKCPNSAT SLSQDNRKKE QDGGDPNEET PM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RY12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 42 nTPM
  • spinal cord: 19 nTPM
  • midbrain: 19 nTPM
  • amygdala: 14 nTPM
  • hippocampal formation: 10 nTPM
  • hypothalamus: 9.2 nTPM

Single-cell type

  • microglia: 1,603 nCPM
  • platelets: 538 nCPM
  • kupffer cells: 100 nCPM
  • macrophages: 58 nCPM
  • hematopoietic stem cells: 52 nCPM
  • megakaryocyte progenitors: 42 nCPM

Immune cell

  • intermediate monocyte: 8.3 nTPM
  • myeloid DC: 3.2 nTPM
  • non-classical monocyte: 2.2 nTPM
  • classical monocyte: 1.9 nTPM
  • total PBMC: 1.3 nTPM
  • naive B-cell: 0.5 nTPM

Brain region

  • white matter: 32 nTPM
  • medulla oblongata: 27 nTPM
  • spinal cord: 26 nTPM
  • thalamus: 20 nTPM
  • pons: 20 nTPM
  • hypothalamus: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about P2RY12.

Disease | AllUniProt

Conditions P2RY12 is implicated in, by any mechanism.

  • Bleeding disorder, platelet-type, 8 (BDPLT8) MIM:609821

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 135 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Platelet-type bleeding disorder 8
  • Impaired ADP-induced platelet aggregation
  • Abnormal platelet function
  • P2RY12-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
0.86
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RY12 as an antibody target. Whether an autoantibody or antibody against P2RY12 could matter depends on whether native P2RY12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RY12 is annotated at the cell surface, where native P2RY12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RY12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/P2RY12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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