Seroatlas · Human Serome Atlas

P2RY11

P2Y purinoceptor 11

Also known as: P2Y11, P2Y11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96G91
Gene: P2RY11
Ensembl: ENSG00000244165
Chromosome: 19
Canonical length: 374 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>Q96G91|P2RY11
     1  MAANVSGAKS CPANFLAAAD DKLSGFQGDF LWPILVVEFL VAVASNGLAL YRFSIRKQRP
    61  WHPAVVFSVQ LAVSDLLCAL TLPPLAAYLY PPKHWRYGEA ACRLERFLFT CNLLGSVIFI
   121  TCISLNRYLG IVHPFFARSH LRPKHAWAVS AAGWVLAALL AMPTLSFSHL KRPQQGAGNC
   181  SVARPEACIK CLGTADHGLA AYRAYSLVLA GLGCGLPLLL TLAAYGALGR AVLRSPGMTV
   241  AEKLRVAALV ASGVALYASS YVPYHIMRVL NVDARRRWST RCPSFADIAQ ATAALELGPY
   301  VGYQVMRGLM PLAFCVHPLL YMAAVPSLGC CCRHCPGYRD SWNPEDAKST GQALPLNATA
   361  APKPSEPQSR ELSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RY11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

skin: 17 nTPM
spleen: 15 nTPM
cerebral cortex: 14 nTPM
basal ganglia: 13 nTPM
cerebellum: 13 nTPM
hippocampal formation: 13 nTPM

Single-cell type

nk-cells: 16 nCPM
microglia: 12 nCPM
renal connecting tubule cells: 7.4 nCPM
t-cells: 6.6 nCPM
hepatic stellate cells: 6.5 nCPM
sertoli cells: 6.5 nCPM

Immune cell

MAIT T-cell: 19 nTPM
NK-cell: 14 nTPM
gdT-cell: 7.3 nTPM
memory CD8 T-cell: 6.9 nTPM
naive CD8 T-cell: 5.5 nTPM
total PBMC: 4.9 nTPM

Brain region

thalamus: 15 nTPM
cerebral cortex: 14 nTPM
basal ganglia: 14 nTPM
medulla oblongata: 13 nTPM
hippocampal formation: 12 nTPM
pons: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0.01
gnomAD missense Z: -1.47
DepMap mean gene effect: -0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
P2Y purinoceptor 11

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RY11 as an antibody target. Whether an autoantibody or antibody against P2RY11 could matter depends on whether native P2RY11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RY11 is annotated at the cell surface, where native P2RY11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RY11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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