Seroatlas · Human Serome Atlas

P2RY10

Putative P2Y purinoceptor 10

Also known as: P2Y10, P2Y10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00398
Gene: P2RY10
Ensembl: ENSG00000078589
Chromosome: X
Canonical length: 339 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>O00398|P2RY10
     1  MANLDKYTET FKMGSNSTST AEIYCNVTNV KFQYSLYATT YILIFIPGLL ANSAALWVLC
    61  RFISKKNKAI IFMINLSVAD LAHVLSLPLR IYYYISHHWP FQRALCLLCF YLKYLNMYAS
   121  ICFLTCISLQ RCFFLLKPFR ARDWKRRYDV GISAAIWIVV GTACLPFPIL RSTDLNNNKS
   181  CFADLGYKQM NAVALVGMIT VAELAGFVIP VIIIAWCTWK TTISLRQPPM AFQGISERQK
   241  ALRMVFMCAA VFFICFTPYH INFIFYTMVK ETIISSCPVV RIALYFHPFC LCLASLCCLL
   301  DPILYYFMAS EFRDQLSRHG SSVTRSRLMS KESGSSMIG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RY10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

lymph node: 26 nTPM
tonsil: 24 nTPM
spleen: 16 nTPM
appendix: 14 nTPM
thymus: 9.6 nTPM
bone marrow: 7.7 nTPM

Single-cell type

b-cells: 119 nCPM
t-cells: 107 nCPM
plasma cells: 64 nCPM
nk-cells: 48 nCPM
innate lymphoid cells: 45 nCPM
cdc: 41 nCPM

Immune cell

basophil: 257 nTPM
eosinophil: 158 nTPM
naive B-cell: 74 nTPM
memory B-cell: 73 nTPM
T-reg: 42 nTPM
memory CD4 T-cell: 28 nTPM

Brain region

cerebellum: 13 nTPM
cerebral cortex: 11 nTPM
white matter: 10 nTPM
basal ganglia: 10 nTPM
hypothalamus: 9.4 nTPM
thalamus: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0.16
gnomAD missense Z: 1.36
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RY10 as an antibody target. Whether an autoantibody or antibody against P2RY10 could matter depends on whether native P2RY10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RY10 is annotated at the cell surface, where native P2RY10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RY10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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