P2RY1
P2Y purinoceptor 1
Also known as: P2RY1_HUMAN, P2Y1, SARCC
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P47900
- Gene
- P2RY1
- Ensembl
- ENSG00000169860
- Chromosome
- 3
- Canonical length
- 373 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins, Transporters
OverviewNCBI Gene
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
373 residues, UniProt reviewed canonical sequence.
>P47900|P2RY1
1 MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ FYYLPAVYIL
61 VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY VLTLPALIFY YFNKTDWIFG
121 DAMCKLQRFI FHVNLYGSIL FLTCISAHRY SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV
181 VAISPILFYS GTGVRKNKTI TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI
241 VRALIYKDLD NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND
301 RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL QSKSEDMTLN
361 ILPEFKQNGD TSLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against P2RY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- placenta: 24 nTPM
- esophagus: 18 nTPM
- basal ganglia: 12 nTPM
- colon: 9.5 nTPM
- skin: 8.4 nTPM
- retina: 8.3 nTPM
Single-cell type
- platelets: 202 nCPM
- pituicytes/fscs: 114 nCPM
- prostatic glandular cells: 66 nCPM
- megakaryocytes: 50 nCPM
- astrocytes: 48 nCPM
- esophageal suprabasal cells: 47 nCPM
Immune cell
- basophil: 6 nTPM
- non-classical monocyte: 2.7 nTPM
- intermediate monocyte: 0.6 nTPM
- plasmacytoid DC: 0.5 nTPM
- myeloid DC: 0.3 nTPM
- total PBMC: 0.1 nTPM
Brain region
- basal ganglia: 31 nTPM
- pons: 19 nTPM
- hypothalamus: 18 nTPM
- amygdala: 14 nTPM
- hippocampal formation: 13 nTPM
- spinal cord: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.6
- gnomAD pLI
- 0.52
- gnomAD missense Z
- 1.61
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
- blood vessel diameter maintenance
- cell surface receptor signaling pathway
- cellular response to ATP
- cellular response to purine-containing compound
- eating behavior
- establishment of localization in cell
- G protein-coupled adenosine receptor signaling pathway
- G protein-coupled purinergic nucleotide receptor signaling pathway
- G protein-coupled receptor signaling pathway
- glial cell migration
- monoatomic ion transport
- negative regulation of norepinephrine secretion
- phospholipase C-activating G protein-coupled receptor signaling pathway
- platelet activation
- positive regulation of cytosolic calcium ion concentration
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of hormone secretion
- positive regulation of inositol trisphosphate biosynthetic process
- positive regulation of monoatomic ion transport
- positive regulation of penile erection
- positive regulation of transcription by RNA polymerase II
- protein localization to plasma membrane
- regulation of cell shape
- regulation of presynaptic cytosolic calcium ion concentration
- regulation of synaptic vesicle exocytosis
- relaxation of muscle
- response to growth factor
- response to mechanical stimulus
- signal transduction involved in regulation of gene expression
Molecular functions
- A1 adenosine receptor binding
- ADP binding
- ATP binding
- G protein-coupled ADP receptor activity
- G protein-coupled ATP receptor activity
- G protein-coupled purinergic nucleotide receptor activity
- protein heterodimerization activity
- scaffold protein binding
- signaling receptor activity
- signaling receptor regulator activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads P2RY1 as an antibody target. Whether an autoantibody or antibody against P2RY1 could matter depends on whether native P2RY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
P2RY1 is annotated at the cell surface, where native P2RY1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label P2RY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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