Seroatlas · Human Serome Atlas

OXTR

Oxytocin receptor

Also known as: OTR, OXYR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P30559
Gene: OXTR
Ensembl: ENSG00000180914
Chromosome: 3
Canonical length: 389 aa
Protein class: FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>P30559|OXTR
     1  MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL LLALSGNACV
    61  LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV
   121  VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV
   181  ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA
   241  AEAPEGAAAG DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW
   301  DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGRRLGET
   361  SASKKSNSSS FVLSHRSSSQ RSCSQPSTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OXTR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

breast: 51 nTPM
midbrain: 10 nTPM
basal ganglia: 7.5 nTPM
hypothalamus: 5.1 nTPM
cerebral cortex: 4.1 nTPM
spinal cord: 3.4 nTPM

Single-cell type

breast myoepithelial cells: 578 nCPM
platelets: 62 nCPM
respiratory ciliated cells: 29 nCPM
fallopian tube ciliated cells: 23 nCPM
cardiomyocytes: 17 nCPM
adrenal medulla cells: 11 nCPM

Immune cell

neutrophil: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 32 nTPM
hypothalamus: 30 nTPM
midbrain: 28 nTPM
spinal cord: 26 nTPM
basal ganglia: 18 nTPM
pons: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 1.16
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

vasopressin receptor activity
oxytocin receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OXTR as an antibody target. Whether an autoantibody or antibody against OXTR could matter depends on whether native OXTR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OXTR is annotated at the cell surface, where native OXTR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OXTR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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