Seroatlas · Human Serome Atlas

OXT

Oxytocin-neurophysin 1

Also known as: NEU1_HUMAN, OT, OT-NPI, OXT-NPI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01178
Gene: OXT
Ensembl: ENSG00000101405
Chromosome: 20
Canonical length: 125 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>P01178|OXT
     1  MAGPSLACCL LGLLALTSAC YIQNCPLGGK RAAPDLDVRK CLPCGPGGKG RCFGPNICCA
    61  EELGCFVGTA EALRCQEENY LPSPCQSGQK ACGSGGRCAV LGLCCSPDGC HADPACDAEA
   121  TFSQR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OXT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 2,932 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 2,932 nTPM
liver: 19 nTPM
pituitary gland: 16 nTPM
midbrain: 12 nTPM
kidney: 4.9 nTPM
basal ganglia: 4.8 nTPM

Single-cell type

other brain neurons: 1,009 nCPM
late spermatids: 134 nCPM
oocytes: 134 nCPM
hepatocytes: 53 nCPM
early spermatids: 27 nCPM
epididymal efferent duct absorptive cells: 25 nCPM

Immune cell

eosinophil: 3.4 nTPM
memory B-cell: 2.1 nTPM
naive CD8 T-cell: 1.7 nTPM
naive B-cell: 1.6 nTPM
naive CD4 T-cell: 1.4 nTPM
T-reg: 1.3 nTPM

Brain region

hypothalamus: 2,524 nTPM
basal ganglia: 18 nTPM
thalamus: 17 nTPM
cerebral cortex: 3.3 nTPM
spinal cord: 3.2 nTPM
choroid plexus: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0.71
gnomAD missense Z: 0.79
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OXT as an antibody target. Whether an autoantibody or antibody against OXT could matter depends on whether native OXT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OXT is annotated as secreted, so native OXT circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OXT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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