Seroatlas · Human Serome Atlas

OXLD1

Oxidoreductase-like domain-containing protein 1

Also known as: C17orf90, MGC104712, OXLD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5BKU9
Gene: OXLD1
Ensembl: ENSG00000204237
Chromosome: 17
Canonical length: 147 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>Q5BKU9|OXLD1
     1  MLLRRVVEGG RAVAAAVRGS GARRFSSPDC CQRLPGGGSF LQRHHPGAQA PDGRRKFGTD
    61  HVEVGSQAGA DGTRPPKASL PPELQPPTNC CMSGCPNCVW VEYADRLLQH FQDGGERALA
   121  ALEEHVADEN LKAFLRMEIR LHTRCGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OXLD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

testis: 29 nTPM
liver: 18 nTPM
skeletal muscle: 17 nTPM
adrenal gland: 16 nTPM
basal ganglia: 16 nTPM
amygdala: 15 nTPM

Single-cell type

late primary spermatocytes: 191 nCPM
epididymal principal cells: 83 nCPM
esophageal apical cells: 80 nCPM
esophageal suprabasal cells: 73 nCPM
early spermatids: 69 nCPM
esophageal basal cells: 63 nCPM

Immune cell

NK-cell: 36 nTPM
naive CD4 T-cell: 34 nTPM
memory CD4 T-cell: 32 nTPM
plasmacytoid DC: 31 nTPM
T-reg: 31 nTPM
naive B-cell: 29 nTPM

Brain region

white matter: 9.4 nTPM
spinal cord: 8.7 nTPM
thalamus: 8.7 nTPM
hypothalamus: 8.6 nTPM
medulla oblongata: 8.6 nTPM
cerebral cortex: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0.27
gnomAD missense Z: -0.3
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

Oxidoreductase-like, N-terminal
Oxidoreductase-like protein, N-terminal
Oxidoreductase-like domain-containing protein 1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OXLD1 as an antibody target. Whether an autoantibody or antibody against OXLD1 could matter depends on whether native OXLD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OXLD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OXLD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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