OXER1
Oxoeicosanoid receptor 1
Also known as: GPCR, GPR170, OXER1_HUMAN, TG1019
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TDS5
- Gene
- OXER1
- Ensembl
- ENSG00000162881
- Chromosome
- 2
- Canonical length
- 384 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
Enables G protein-coupled receptor activity and icosanoid binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
384 residues, UniProt reviewed canonical sequence.
>Q8TDS5|OXER1
1 MELHNLSSPS PSLSSSVLPP SFSPSPSSAP SAFTTVGGSS GGPCHPTSSS LVSAFLAPIL
61 ALEFVLGLVG NSLALFIFCI HTRPWTSNTV FLVSLVAADF LLISNLPLRV DYYLLHETWR
121 FGAAACKVNL FMLSTNRTAS VVFLTAIALN RYLKVVQPHH VLSRASVGAA ARVAGGLWVG
181 ILLLNGHLLL STFSGPSCLS YRVGTKPSAS LRWHQALYLL EFFLPLALIL FAIVSIGLTI
241 RNRGLGGQAG PQRAMRVLAM VVAVYTICFL PSIIFGMASM VAFWLSACRS LDLCTQLFHG
301 SLAFTYLNSV LDPVLYCFSS PNFLHQSRAL LGLTRGRQGP VSDESSYQPS RQWRYREASR
361 KAEAIGKLKV QGEVSLEKEG SSQGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OXER1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 56 nTPM
Expression across tissuesHPA
Tissue
- liver: 56 nTPM
- ovary: 9 nTPM
- kidney: 8.3 nTPM
- small intestine: 8 nTPM
- cervix: 6.8 nTPM
- pancreas: 6.8 nTPM
Single-cell type
- enterocytes: 14 nCPM
- hepatocytes: 11 nCPM
- proximal tubule cells: 7.5 nCPM
- retinal amacrine cells: 5.4 nCPM
- melanocytes: 5.1 nCPM
- neutrophils: 5.1 nCPM
Immune cell
- eosinophil: 158 nTPM
- basophil: 74 nTPM
- neutrophil: 19 nTPM
- classical monocyte: 1.9 nTPM
- myeloid DC: 1.5 nTPM
- total PBMC: 0.9 nTPM
Brain region
- amygdala: 4.7 nTPM
- cerebral cortex: 4.7 nTPM
- choroid plexus: 4.7 nTPM
- hippocampal formation: 4.7 nTPM
- medulla oblongata: 4.3 nTPM
- thalamus: 4.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.98
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.6
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
- G protein-coupled receptor signaling pathway
Molecular functions
- G protein-coupled receptor activity
- 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
- 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
- 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OXER1 as an antibody target. Whether an autoantibody or antibody against OXER1 could matter depends on whether native OXER1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OXER1 is annotated at the cell surface, where native OXER1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label OXER1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...