OXCT2

Protein identityUniProt · HPA

UniProt accession

Q9BYC2

Gene

OXCT2

Ensembl

ENSG00000198754

Chromosome

1

Canonical length

517 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q9BYC2|OXCT2
     1  MAALRLLASV LGRGVPAGGS GLALSQGCAR CFATSPRLRA KFYADPVEMV KDISDGATVM
    61  IGGFGLCGIP ENLIAALLRT RVKDLQVVSS NVGVEDFGLG LLLAARQVRR IVCSYVGENT
   121  LCESQYLAGE LELELTPQGT LAERIRAGGA GVPAFYTPTG YGTLVQEGGA PIRYTPDGHL
   181  ALMSQPREVR EFNGDHFLLE RAIRADFALV KGWKADRAGN VVFRRSARNF NVPMCKAADV
   241  TAVEVEEIVE VGAFPPEDIH VPNIYVDRVI KGQKYEKRIE RLTILKEEDG DAGKEEDART
   301  RIIRRAALEF EDGMYANLGI GIPLLASNFI SPSMTVHLHS ENGILGLGPF PTEDEVDADL
   361  INAGKQTVTV LPGGCFFASD DSFAMIRGGH IQLTMLGAMQ VSKYGDLANW MIPGKKVKGM
   421  GGAMDLVSSQ KTRVVVTMQH CTKDNTPKIM EKCTMPLTGK RCVDRIITEK AVFDVHRKKE
   481  LTLRELWEGL TVDDIKKSTG CAFAVSPNLR PMQQVAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OXCT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

70 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.96

gnomAD pLI

0

gnomAD missense Z

0.64

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ketone body catabolic process
• ketone body metabolic process

Molecular functions

• succinyl-CoA:3-oxo-acid CoA-transferase activity

Cellular components

• mitochondrial matrix
• mitochondrion
• motile cilium

Protein domainsUniProt · Pfam · InterPro

• Coenzyme A transferase binding site
• Coenzyme A transferase active site
• Coenzyme A transferase family I
• 3-oxoacid CoA-transferase, subunit B
• 3-oxoacid CoA-transferase, subunit A
• 3-oxoacid CoA-transferase
• NagB/RpiA transferase-like
• Coenzyme A transferase

KeywordsUniProt

• Mitochondrion
• Transferase
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of OXCT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BCKDHA