Seroatlas · Human Serome Atlas

OXCT1

Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

Also known as: OXCT, SCOT, SCOT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55809
Gene
OXCT1
Ensembl
ENSG00000083720
Chromosome
5
Canonical length
520 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Mitochondria
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>P55809|OXCT1
     1  MAALKLLSSG LRLCASARGS GATWYKGCVC SFSTSAHRHT KFYTDPVEAV KDIPDGATVL
    61  VGGFGLCGIP ENLIDALLKT GVKGLTAVSN NAGVDNFGLG LLLRSKQIKR MVSSYVGENA
   121  EFERQYLSGE LEVELTPQGT LAERIRAGGA GVPAFYTPTG YGTLVQEGGS PIKYNKDGSV
   181  AIASKPREVR EFNGQHFILE EAITGDFALV KAWKADRAGN VIFRKSARNF NLPMCKAAET
   241  TVVEVEEIVD IGAFAPEDIH IPQIYVHRLI KGEKYEKRIE RLSIRKEGDG EAKSAKPGDD
   301  VRERIIKRAA LEFEDGMYAN LGIGIPLLAS NFISPNITVH LQSENGVLGL GPYPRQHEAD
   361  ADLINAGKET VTILPGASFF SSDESFAMIR GGHVDLTMLG AMQVSKYGDL ANWMIPGKMV
   421  KGMGGAMDLV SSAKTKVVVT MEHSAKGNAH KIMEKCTLPL TGKQCVNRII TEKAVFDVDK
   481  KKGLTLIELW EGLTVDDVQK STGCDFAVSP KLMPMQQIAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OXCT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
230 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 230 nTPM
  • thymus: 72 nTPM
  • cerebral cortex: 58 nTPM
  • kidney: 50 nTPM
  • adipose tissue: 50 nTPM
  • parathyroid gland: 46 nTPM

Single-cell type

  • epididymal clear cells: 535 nCPM
  • parietal cells: 265 nCPM
  • breast lactating cells: 197 nCPM
  • cardiomyocytes: 141 nCPM
  • respiratory ionocytes: 132 nCPM
  • t-cells: 123 nCPM

Immune cell

  • T-reg: 22 nTPM
  • MAIT T-cell: 14 nTPM
  • naive CD4 T-cell: 14 nTPM
  • memory CD8 T-cell: 13 nTPM
  • gdT-cell: 12 nTPM
  • memory CD4 T-cell: 12 nTPM

Brain region

  • cerebral cortex: 70 nTPM
  • basal ganglia: 67 nTPM
  • hippocampal formation: 54 nTPM
  • hypothalamus: 52 nTPM
  • thalamus: 50 nTPM
  • white matter: 46 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OXCT1.

Disease | AllUniProt

Conditions OXCT1 is implicated in, by any mechanism.

  • Succinyl-CoA:3-oxoacid CoA transferase deficiency (SCOTD) MIM:245050

Disease | GeneticClinVar

22 pathogenic / likely-pathogenic of 274 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Succinyl-CoA acetoacetate transferase deficiency
  • OXCT1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0
gnomAD missense Z
2.57
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OXCT1 as an antibody target. Whether an autoantibody or antibody against OXCT1 could matter depends on whether native OXCT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OXCT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OXCT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OXCT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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