OVOL3
Putative transcription factor ovo-like protein 3
Also known as: HOVO3, OVOL3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O00110
- Gene
- OVOL3
- Ensembl
- ENSG00000105261
- Chromosome
- 19
- Canonical length
- 190 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Vesicles,Cytosol
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in epidermal cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
190 residues, UniProt reviewed canonical sequence.
>O00110|OVOL3
1 MPRAFLVRSR RPQPPNWGHL PDQLRGDAYI PDCSSLGGPP AQQSSSVRDP WTAQPTQGNL
61 TSAPRGPGTL GCPLCPKAFP LQRMLTRHLK CHSPVRRHLC RCCGKGFHDA FDLKRHMRTH
121 TGIRPFRCSA CGKAFTQRCS LEAHLAKVHG QPASYAYRER REKLHVCEDC GFTSSRPDTY
181 AQHRALHRAALocalizationUniProt · AlphaFold · HPA
Whether an antibody against OVOL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 3.6 nTPM
Expression across tissuesHPA
Tissue
- testis: 3.6 nTPM
- skin: 0.8 nTPM
- pituitary gland: 0.3 nTPM
- appendix: 0.2 nTPM
- retina: 0.2 nTPM
- skeletal muscle: 0.2 nTPM
Single-cell type
- tuft cells: 12 nCPM
- cone photoreceptor cells: 6.2 nCPM
- respiratory ionocytes: 5.1 nCPM
- rod photoreceptor cells: 3.3 nCPM
- early primary spermatocytes: 3.1 nCPM
- plasma cells: 3 nCPM
Immune cell
- eosinophil: 0.3 nTPM
- MAIT T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebellum: 10 nTPM
- white matter: 9.7 nTPM
- cerebral cortex: 6.4 nTPM
- pons: 5.8 nTPM
- basal ganglia: 5.7 nTPM
- medulla oblongata: 5.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.14
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.96
OntologyGO
Biological processes
- epidermal cell differentiation
- negative regulation of cell differentiation
- negative regulation of DNA-templated transcription
- negative regulation of signal transduction
- regulation of keratinocyte differentiation
- regulation of keratinocyte proliferation
- regulation of transcription by RNA polymerase II
- negative regulation of multicellular organismal process
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OVOL3 as an antibody target. Whether an autoantibody or antibody against OVOL3 could matter depends on whether native OVOL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OVOL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label OVOL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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