OVOL1
Putative transcription factor Ovo-like 1
Also known as: HOVO1, OVOL1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O14753
- Gene
- OVOL1
- Ensembl
- ENSG00000172818
- Chromosome
- 11
- Canonical length
- 267 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011]
Canonical amino-acid sequenceUniProt
267 residues, UniProt reviewed canonical sequence.
>O14753|OVOL1
1 MPRAFLVKKP CVSTCKRNWS ELPDEERGEI YVPVSLGFCP PQPYREPEPS VAEPPSCPLA
61 LNMSLRDSSY SMAPGPCVVA QLPSEDMGHL TDPQSRDHGF LRTKMKVTLG DSPSGDLFTC
121 RVCQKAFTYQ RMLNRHMKCH NDVKRHLCTY CGKGFNDTFD LKRHVRTHTG VRPYKCSLCD
181 KAFTQRCSLE SHLKKIHGVQ QKYAYKERRA KLYVCEECGC TSESQEGHVL HLKEHHPDSP
241 LLRKTSKKVA VALQNTVTSL LQGSPHLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OVOL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 55 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 55 nTPM
- skin: 49 nTPM
- testis: 34 nTPM
- urinary bladder: 26 nTPM
- vagina: 20 nTPM
- cervix: 19 nTPM
Single-cell type
- esophageal apical cells: 604 nCPM
- syncytiotrophoblasts: 392 nCPM
- urothelial cells: 243 nCPM
- esophageal suprabasal cells: 233 nCPM
- late primary spermatocytes: 192 nCPM
- endometrial luminal cells: 163 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.5 nTPM
- cerebral cortex: 0.4 nTPM
- basal ganglia: 0.3 nTPM
- hippocampal formation: 0.3 nTPM
- white matter: 0.3 nTPM
- amygdala: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.42
- gnomAD pLI
- 0.88
- gnomAD missense Z
- 1.37
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- epidermal cell differentiation
- germline cell cycle switching, mitotic to meiotic cell cycle
- keratinocyte proliferation
- kidney development
- mesoderm development
- negative regulation of keratinocyte proliferation
- negative regulation of stem cell proliferation
- regulation of transcription by RNA polymerase II
- skin development
- spermatogenesis
- stem cell proliferation
- meiotic cell cycle phase transition
- negative regulation of meiotic cell cycle phase transition
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OVOL1 as an antibody target. Whether an autoantibody or antibody against OVOL1 could matter depends on whether native OVOL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OVOL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label OVOL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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